Related Experiment Videos
Critical micelle concentration and hemolytic activity--a correlation suggested by the marine sterol, halistanol
R W Moni1, P G Parsons, R J Quinn
1School of Science, Griffith University, Brisbane, Queensland, Australia.
Biochemical and Biophysical Research Communications
|January 15, 1992
Abstract:
The marine natural product, halistanol trisulfate, has a relatively low critical micelle concentration of 0.001% m/v (14.5 microM) and strong hemolytic potency with an EC50 of 0.00046% m/v (6.67 microM). As expected of a detergent, it inhibits the growth of gram-positive but not gram-negative bacteria. The hemolytic activity of halistanol trisulfate and other detergents has been shown to correlate with critical micelle concentration. This correlation may have important implications in the mechanism of membranolytic bioactivity.