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Updated: Jul 16, 2026
05:22
Iris Fixation via External Pentagram Suturing
Published on: May 5, 2022
[Iridocorneal endothelial syndrome and glaucoma]
1Service d'Ophtalmologie, Pavillon C, Hôpital Edouard Herriot, 5, place d'Arsonval, 69437 Lyon Cedex 03, France. philippe.denis@chu-lyon.fr
Journal Francais D'Ophtalmologie
|February 24, 2007
Summary
Iridocorneal endothelial (ICE) syndrome involves abnormal corneal cells leading to eye problems like swelling and glaucoma. This progressive condition, often affecting young women, requires careful management of eye pressure and potential surgical interventions.
Area of Science:
- Ophthalmology
- Cell Biology
Context:
- Iridocorneal endothelial (ICE) syndrome is a rare group of unilateral ocular disorders.
- Characterized by corneal proliferative endotheliopathy, it includes essential iris atrophy, Chandler's syndrome, and Cogan-Reese syndrome.
Purpose:
- To describe the clinical features, pathogenesis, and management of Iridocorneal endothelial (ICE) syndrome.
- To highlight the challenges in managing secondary glaucoma associated with ICE syndrome.
Summary:
- ICE syndrome results from abnormal corneal endothelial cells, leading to corneal edema, peripheral anterior synechiae, and iris abnormalities.
- The pathogenesis involves endothelial cell migration affecting the trabecular meshwork and iris.
- It commonly affects young adult females and is progressive, often leading to difficult-to-manage secondary glaucoma.
Impact:
- Understanding ICE syndrome pathogenesis aids in developing targeted therapies.
- Early surgical intervention for glaucoma may improve outcomes, though endothelialization poses a risk.
- This research emphasizes the need for specialized care for patients with ICE syndrome and associated glaucoma.
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