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[Conductive bone substitute material with variable antibiotic delivery].

C Englert1, P Angele, J Fierlbeck

  • 1Abteilung Unfallchirurgie, Klinikum der Universität, Franz-Josef-Strauss-Allee 11, 93053, Regensburg, Germany. Carsten.Englert@klinik.uni-regensburg.de

Der Unfallchirurg
|February 24, 2007
PubMed
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This study introduces PerOssal, a new bone substitute with hydroxylapatite and calcium sulfate. It demonstrates osteoconductive and degradable properties, offering prolonged antibiotic release and sufficient mechanical strength for bone defect repair.

Area of Science:

  • Biomaterials Science
  • Orthopedic Surgery
  • Drug Delivery Systems

Background:

  • A novel bone substitute, PerOssal, composed of hydroxylapatite and calcium sulfate, was developed in two distinct formulations.
  • This material exhibits inherent osteoconductive and degradable characteristics, featuring a capillary structure for rapid fluid absorption.
  • The integrated capillary structure facilitates the absorption of antibiotics, enabling a sustained release profile.

Purpose of the Study:

  • To evaluate the mechanical properties of the two PerOssal formulations under varying hydration conditions.
  • To assess the elution kinetics and efficacy of antibiotics (vancomycin and gentamicin) released from the bone substitute.
  • To determine the suitability of PerOssal as a bone graft material with integrated antibiotic delivery capabilities.

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Main Methods:

  • Mechanical strength was quantified using unconfined compression tests on both wet and dry samples of each formulation.
  • Antibiotic release was monitored microbiologically over a 10-day period using the agar diffusion assay for vancomycin and gentamicin.
  • In vitro analysis determined the concentration of eluted antibiotics relative to the minimal inhibitory concentration (MIC) for key pathogens.

Main Results:

  • Both vancomycin and gentamicin demonstrated a prolonged release rate over 10 days, with concentrations exceeding MICs for common pathogens at day 10.
  • Formulation two exhibited significantly superior mechanical strength in both wet and dry states compared to formulation one.
  • While both formulations experienced a reduction in strength when wet, formulation two's wet strength was comparable to formulation one's dry strength.

Conclusions:

  • PerOssal is a viable degradable, osteoconductive bone substitute capable of delivering effective antibiotic doses over 10 days.
  • The mechanical integrity of PerOssal is adequate for supporting cancellous bone defects in non-load-bearing applications or when combined with osteosynthesis.
  • The dual functionality of PerOssal—bone regeneration and localized antibiotic delivery—offers a promising solution for orthopedic applications.