Related Experiment Video
Updated: Jul 16, 2026
09:25
The Treadmill Fatigue Test: A Simple, High-throughput Assay of Fatigue-like Behavior for the Mouse
Published on: May 31, 2016
Modafinil's use in combating interferon-induced fatigue
Kari A Martin1, Lois E Krahn, Vijayan Balan
1Department of Psychiatry and Psychology, Mayo Clinic Arizona, 13400 East Shea Boulevard, Scottsdale, AZ 85259, USA. martin.kariann@mayo.edu
Digestive Diseases and Sciences
|February 24, 2007
Summary
Interferon therapy for hepatitis C can cause depression. Depression-specific symptoms improve with antidepressants, while neurovegetative symptoms are more resistant to treatment.
Area of Science:
- Neuroscience
- Hepatology
- Psychiatry
Background:
- Interferon (IFN) is a key treatment for chronic viral hepatitis C.
- Neuropsychiatric side effects, including depression, often complicate IFN therapy.
Purpose of the Study:
- To characterize the distinct syndromes of interferon-alpha-induced depression.
- To evaluate the treatment response of these syndromes to antidepressants.
Main Methods:
- The study analyzed patient data on depression symptoms during interferon therapy.
- Symptom patterns and response to serotoninergic antidepressants were assessed.
Main Results:
- Depression-specific symptoms (e.g., low mood, anxiety) peaked at 12 weeks and responded to antidepressants.
- Neurovegetative symptoms (e.g., fatigue, anorexia) appeared early, persisted, and were less responsive to antidepressants.
Conclusions:
- Interferon-alpha-induced depression comprises two distinct syndromes.
- Targeted antidepressant therapy may alleviate depression-specific symptoms, but neurovegetative symptoms require different management strategies.
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