Evaluation of a possible sex difference in recombination for the ABO-AK linkage

Thirty-five informative families were scored for linkage between the ABO and AK loci. The recombination fractions were estimated separately in females and males and were compared with values reported in the literature. A 1.33:1 ratio for the female:male recombination fraction was obtained by combining all sources, but the difference between the recombination fractions was not significantly different from zero. The present data, combined with those reported earlier, show that the most likely recombination fraction is about 14%.