Low-barrier hydrogen bonds and low fractionation factor bases in enzymatic reactions

pH-rate profiles support a general base mechanism for galactokinase (Lactococcus lactis).

FEBS letters·2013

Oxamate is an alternative substrate for pyruvate carboxylase from Rhizobium etli.

Biochemistry·2013

Catalytic mechanism of perosamine N-acetyltransferase revealed by high-resolution X-ray crystallographic studies and kinetic analyses.

Biochemistry·2012

A kinetic and isotope effect investigation of the urease-catalyzed hydrolysis of hydroxyurea.

Biochemistry·2010

13C isotope effect on the reaction catalyzed by prephenate dehydratase.

Biochimica et biophysica acta·2009

A heavy-atom isotope effect and kinetic investigation of the hydrolysis of semicarbazide by urease from jack bean (Canavalia ensiformis).

Biochemistry·2008

Triprolidine Interferes with α-Synuclein Fibrillation and Remodels Aggregate Structure via Conformational Modulation.

Biochemistry·2026

The Photocycle of the Red Light-Sensitive Plant-like Cryptochrome CryP from Phaeodactylum tricornutum.

Biochemistry·2026

Chemical Pathway-Dependent Structural Reorganization at a Hinge Microenvironment in the AcrA Adaptor Protein.

Biochemistry·2026

Improved Protein Semi-Synthesis Enables Biophysical Studies of Thioamide Destabilization of β-Sheet Interactions.

Biochemistry·2026

Recognition of Single-Strand-Duplex Junctions in RNA Using Peptide Nucleic Acids That Form Watson-Crick and Hoogsteen Hydrogen Bond.

Biochemistry·2026

A Molecular Mechanistic Deep Dive into 14-3-3 Molecular Glue Cooperativity.

Biochemistry·2026

Dynamically biased microcanonical treatment of HCl dissociative chemisorption on Au(111) yields thermal associative desorption dynamics by detailed balance.

The Journal of chemical physics·2026

Solvation thermodynamics revisited.

The Journal of chemical physics·2026

Molecular dynamics analysis of 3' dangling-end stabilization at an AU-rich RNA helix terminus.

Journal of biomolecular structure & dynamics·2026

Computer models predict differential dendritic vulnerability with ischemia and spreading depression.

PLoS computational biology·2026

AMOEBA Polarizable Atomic Multipole Force Field Parameters for Flavins.

Journal of chemical theory and computation·2026

Piecewise Constraints for Exact End Point Sampling with λ-Dynamics.

Journal of chemical theory and computation·2026

Related Experiment Videos

Low-barrier hydrogen bonds and low fractionation factor bases in enzymatic reactions

Related Concept Videos

pH-rate profiles support a general base mechanism for galactokinase (Lactococcus lactis).

Oxamate is an alternative substrate for pyruvate carboxylase from Rhizobium etli.

Catalytic mechanism of perosamine N-acetyltransferase revealed by high-resolution X-ray crystallographic studies and kinetic analyses.

A kinetic and isotope effect investigation of the urease-catalyzed hydrolysis of hydroxyurea.

13C isotope effect on the reaction catalyzed by prephenate dehydratase.

A heavy-atom isotope effect and kinetic investigation of the hydrolysis of semicarbazide by urease from jack bean (Canavalia ensiformis).

Triprolidine Interferes with α-Synuclein Fibrillation and Remodels Aggregate Structure via Conformational Modulation.

The Photocycle of the Red Light-Sensitive Plant-like Cryptochrome CryP from Phaeodactylum tricornutum.

Chemical Pathway-Dependent Structural Reorganization at a Hinge Microenvironment in the AcrA Adaptor Protein.

Improved Protein Semi-Synthesis Enables Biophysical Studies of Thioamide Destabilization of β-Sheet Interactions.

Recognition of Single-Strand-Duplex Junctions in RNA Using Peptide Nucleic Acids That Form Watson-Crick and Hoogsteen Hydrogen Bond.

A Molecular Mechanistic Deep Dive into 14-3-3 Molecular Glue Cooperativity.

Dynamically biased microcanonical treatment of HCl dissociative chemisorption on Au(111) yields thermal associative desorption dynamics by detailed balance.

Solvation thermodynamics revisited.

Molecular dynamics analysis of 3' dangling-end stabilization at an AU-rich RNA helix terminus.

Computer models predict differential dendritic vulnerability with ischemia and spreading depression.

AMOEBA Polarizable Atomic Multipole Force Field Parameters for Flavins.

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Low-barrier hydrogen bonds and low fractionation factor bases in enzymatic reactions

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