Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Reticulated platelets and uninhibited COX-1 and COX-2 decrease the antiplatelet effects of aspirin.

S Guthikonda1, E I Lev, R Patel

  • 1Department of Cardiology, Emory University, Atlanta, GA 77030, USA. nkleiman@tmh.tmc.edu

Journal of Thrombosis and Haemostasis : JTH
|February 27, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

An odorant receptor mediates the attractiveness of cis-jasmone to Campoletis chlorideae, the endoparasitoid of Helicoverpa armigera.

Insect molecular biology·2018
Same author

Effect of High Dose Statin Pretreatment on Endothelial Progenitor Cells After Percutaneous Coronary Intervention (HIPOCRATES Study).

Cardiovascular drugs and therapy·2015
Same author

The β isoform of the catalytic subunit of protein phosphatase 2B restrains platelet function by suppressing outside-in αII b β3 integrin signaling.

Journal of thrombosis and haemostasis : JTH·2014
Same author

Multilayer vascular grafts based on collagen-mimetic proteins.

Acta biomaterialia·2011
Same author

Erythropoietin increases circulating endothelial progenitor cells and reduces the formation and progression of cerebral aneurysm in rats.

Neuroscience·2011
Same author

Disulfide bond reduction of von Willebrand factor by ADAMTS-13.

Journal of thrombosis and haemostasis : JTH·2010
Same journal

The Natural Mutation Arg221aTrp in Human α-Thrombin Abrogates Physiological Na<sup>+</sup> Binding and Preferentially Hinders the Protease Anticoagulant Functions.

Journal of thrombosis and haemostasis : JTH·2026
Same journal

A historical review of the biological, semantic and clinical aspects of aspirin resistance.

Journal of thrombosis and haemostasis : JTH·2026
Same journal

Association between Thrombus Neutrophil Extracellular Traps Content and Ischemic Stroke Recurrence.

Journal of thrombosis and haemostasis : JTH·2026
Same journal

Peptide-Mediated Inhibition of Surface-Initiated Thrombogenesis.

Journal of thrombosis and haemostasis : JTH·2026
Same journal

Growth differentiation factor-15 and bleeding risk in patients with venous thromboembolism.

Journal of thrombosis and haemostasis : JTH·2026
Same journal

Physiological Anticoagulant Deficiencies: Pathogenesis, Diagnosis, and Clinical Implications.

Journal of thrombosis and haemostasis : JTH·2026
See all related articles

Immature (reticulated) platelets reduce aspirin's antiplatelet effectiveness. Higher reticulated platelet counts correlate with increased aspirin resistance due to uninhibited cyclooxygenase (COX) activity.

Area of Science:

  • Hematology
  • Pharmacology
  • Cardiovascular Medicine

Background:

  • Variability in aspirin's antiplatelet effects is not fully understood.
  • Immature (reticulated) platelets may influence aspirin's efficacy via uninhibited cyclooxygenase (COX)-1 and COX-2.

Purpose of the Study:

  • To investigate the role of reticulated platelets in modulating aspirin's antiplatelet effects.
  • To assess the association between reticulated platelet levels and aspirin resistance.

Main Methods:

  • Platelet function studies in 60 healthy volunteers before and after a single 325-mg aspirin dose.
  • Evaluated platelet aggregation, P-selectin and integrin alpha(IIb)beta(3) expression, serum thromboxane B(2) (TxB(2)) levels, reticulated platelets, and platelet COX-2 expression via flow cytometry.

Related Experiment Videos

Main Results:

  • Higher reticulated platelet levels correlated with increased platelet aggregation and P-selectin/integrin expression.
  • Elevated post-aspirin serum TxB(2) levels and a higher incidence of aspirin resistance were observed in subjects with more reticulated platelets.
  • Platelet COX-2 expression was significantly higher in the upper tertile of reticulated platelets.

Conclusions:

  • Reticulated platelets are linked to reduced antiplatelet effects of aspirin.
  • Increased reticulated platelets may contribute to aspirin resistance through enhanced platelet reactivity and uninhibited COX-1 and COX-2 activity.