Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The continuing search for cancer-causing somatic mutations.

Gillian L Dalgliesh, P Andrew Futreal

    Breast Cancer Research : BCR
    |February 27, 2007
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Germline variants in cancer susceptibility genes among patients with mucosal melanoma.

    NPJ genomic medicine·2026
    Same author

    Editor's Note: Analysis of Immune Signatures in Longitudinal Tumor Samples Yields Insight into Biomarkers of Response and Mechanisms of Resistance to Immune Checkpoint Blockade.

    Cancer discovery·2025
    Same author

    Author Correction: Clonal evolution of hematopoietic stem cells after autologous stem cell transplantation.

    Nature genetics·2025
    Same author

    Distinct Clinicogenomic Features and Immunotherapy Associations in Pulmonary Sarcomatoid Carcinoma: A Multicenter Retrospective Study.

    Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer·2025
    Same author

    Clonal evolution of hematopoietic stem cells after autologous stem cell transplantation.

    Nature genetics·2025
    Same author

    Oncogenic drivers shape the tumor microenvironment in human gliomas.

    bioRxiv : the preprint server for biology·2025
    Same journal

    Exploring LTB-mediated T cell differentiation as a prognostic marker in triple-negative breast cancer.

    Breast cancer research : BCR·2026
    Same journal

    Intraoperative NIR-II fluorescence guidance for precise tumor margin assessment and maximized tissue preservation in breast surgery.

    Breast cancer research : BCR·2026
    Same journal

    Tumour-based DNA methylation markers of breast cancer survival: a pooled analysis of 2157 cases.

    Breast cancer research : BCR·2026
    Same journal

    Comprehensive comparison of homologous recombination deficiency predictors in early-stage triple-negative breast cancer.

    Breast cancer research : BCR·2026
    Same journal

    Breastfeeding shapes a unique tumor-immune landscape in pregnancy-associated breast cancer from GEICAM-EMBARCAM study.

    Breast cancer research : BCR·2026
    Same journal

    FBXO5 regulates RPL23A to promote MDM2-mediated p53 degradation and facilitate malignant progression of breast cancer.

    Breast cancer research : BCR·2026
    See all related articles

    Cancer arises from accumulated DNA mutations. Researchers screened 91 breast cancers, identifying somatic variants in 21 key genes to better understand tumor progression.

    Area of Science:

    • Genomics
    • Cancer Biology
    • Molecular Oncology

    Background:

    • Cancer development is linked to accumulating DNA mutations, including germline and somatic alterations.
    • While many genes are implicated, known mutations do not explain all cancer cases.
    • Advances in human genome sequencing enable large-scale mutation discovery in cancer.

    Discussion:

    • Chanock and colleagues performed a somatic variant screen in 91 breast cancer samples.
    • The study focused on a panel of 21 specific genes critical for tumor progression.
    • This research contributes to identifying novel cancer-associated genes.

    Key Insights:

    • The study identified somatic variants in a set of 21 genes across 91 breast cancer samples.
    • This provides a focused dataset for understanding the genetic landscape of breast cancer.

    Related Experiment Videos

  • The findings aid in pinpointing genes somatically mutated in cancer.

    • Outlook:

    • Further research can validate these findings and explore the functional impact of identified variants.
    • This screening approach can be expanded to larger cohorts and diverse cancer types.
    • Identifying novel somatically mutated genes is crucial for developing targeted cancer therapies.