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Duane retraction syndrome: MRI features in two cases.

D Denis1, D Dauletbekov, G Alessi

  • 1Department of Ophthalmology, North's Hospital, Marseille, France.

Journal of Neuroradiology = Journal De Neuroradiologie
|February 27, 2007
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Magnetic resonance imaging (MRI) reveals that aplasia of the abducens nerve (VI) can cause Duane's retraction syndrome (DRS). This finding, observed even in DRS type II, offers new insights into the condition's pathogenesis.

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Area of Science:

  • Ophthalmology
  • Neurology
  • Radiology

Background:

  • Duane's retraction syndrome (DRS) is a congenital eye movement disorder.
  • Previous neuroimaging studies suggested abducens nerve (VI) aplasia is linked to DRS types I and III.
  • DRS type II was typically associated with a normal abducens nerve on MRI.

Observation:

  • This study utilized brain MRI, specifically 3D T2 weighted images, to examine the cranial nerves in two pediatric patients with DRS.
  • The patients presented with left-sided DRS type II and right-sided DRS type I.
  • The abducens nerve (VI) and oculomotor nerve (III) were visualized, focusing on the brainstem region.

Findings:

  • The abducens nerve (VI) was not observed on the affected side in both pediatric patients.
  • The morphology of the third cranial nerves (oculomotor) was normal in both cases.
  • Aplasia of the abducens nerve (VI) was identified in a patient with DRS type II.

Implications:

  • The findings challenge the established understanding of DRS type II, suggesting abducens nerve (VI) aplasia can occur in this subtype.
  • This expands the spectrum of neuroimaging findings associated with Duane's retraction syndrome.
  • The results provide novel insights into the potential pathogenesis of DRS, highlighting nerve aplasia as a key factor across multiple types.