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Related Concept Videos

Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Histone Modification02:32

Histone Modification

The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone deacetylase,...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Histone Modification02:32

Histone Modification

The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone deacetylase,...
Gene-Environment Interactions01:20

Gene-Environment Interactions

Gene expression is a dynamic process that is significantly influenced by environmental factors. This interaction underlies the complex nature of biological development and the phenotypic differences observed among individuals, even among those with identical genetic makeups. Factors such as radiation, temperature, behavior, nutrition, and stress play pivotal roles in determining how genes are expressed. The concept of the reaction range is central to understanding this interaction. It posits...

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Related Experiment Video

Updated: May 8, 2026

Pattern-based Search of Epigenomic Data Using GeNemo
06:38

Pattern-based Search of Epigenomic Data Using GeNemo

Published on: October 8, 2017

Epigenetics: a landscape takes shape.

Aaron D Goldberg1, C David Allis, Emily Bernstein

  • 1Laboratory of Chromatin Biology, The Rockefeller University, New York, NY 10021, USA.

Cell
|February 27, 2007
PubMed
Summary
This summary is machine-generated.

Epigenetics is a rapidly advancing field. This essay explores its philosophical underpinnings, molecular mechanisms, and future research directions in epigenetic studies.

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Area of Science:

  • Molecular Biology
  • Genetics
  • Developmental Biology

Background:

  • Epigenetics has transitioned from disparate observations to a cohesive scientific discipline.
  • Understanding gene regulation beyond DNA sequence is crucial.

Purpose of the Study:

  • To examine the epistemology of epigenetics.
  • To provide an overview of epigenetic molecular mechanisms.
  • To identify future challenges and opportunities in epigenetic research.

Main Methods:

  • Literature review and synthesis.
  • Conceptual analysis of epigenetic principles.
  • Discussion of current research trends.

Main Results:

  • Epigenetics offers a framework for understanding heritable changes in gene expression.
  • Key molecular mechanisms include DNA methylation and histone modification.
  • The field faces challenges in standardization and mechanistic interpretation.

Conclusions:

  • Epigenetics is a vital area with significant implications for health and disease.
  • Further research is needed to fully elucidate complex epigenetic regulation.
  • Interdisciplinary approaches will be essential for future epigenetic discoveries.