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Updated: Jul 16, 2026

Peptide:MHC Tetramer-based Enrichment of Epitope-specific T cells
13:58

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Published on: October 22, 2012

C3b complexation diversifies naturally processed T cell epitopes

François C Cretin1, Vincent A Serra, Marie-Bernadette Villiers

  • 1Laboratoire d'Immunochimie, Département Réponse et Dynamique Cellulaires, Commissariat à l'Energie Atomique-Grenoble, INSERM Unité 548, Université Joseph Fourier Grenoble, 17 rue des Martyrs, 38054 Grenoble Cedex, France.

Molecular Immunology
|February 27, 2007
PubMed

In addition to its well-established role in innate immunity, the complement component C3 is of critical importance in modulating the humoral response. In this study, we examined the effect of C3b linkage to tetanus toxin (TeNT) in the production of antigenic peptides inside human APC. We purified HLA-DR associated peptides isolated either from TeNT or TeNT-C3b pulsed cells. This study revealed that TeNT-C3b derived antigenic peptides are different and more numerous than TeNT derived peptides. This increased production of antigenic peptides correlated with a C3b-induced TeNT modification of proteolysis. These findings argue in favour of a new role for C3b in the modulation of T cell epitope during antigen processing and presentation.

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