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Updated: Jul 16, 2026
07:23
Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities
Published on: July 29, 2014
Opioids for persistent noncancer pain
Gary McCleane1, Howard S Smith
1Rampark Pain Centre, 2 Rampark Dromore Road, Lurgaqn BT66 7JH, Northern Ireland, UK. gary@mccleane.freeserve.co.uk
The Medical Clinics of North America
|February 27, 2007
Summary
Opioids offer pain relief but their complex nervous system effects are still being uncovered. Recent research continues to reveal new insights into opioid mechanisms, side effects, and optimal clinical applications.
Area of Science:
- Pharmacology
- Neuroscience
- Pain Management
Background:
- Opioids are widely used for pain management, supported by substantial clinical evidence and experience.
- Despite extensive use for over 200 years since morphine isolation, a complete understanding of opioid action is still evolving.
Purpose of the Study:
- To review and synthesize recent scientific publications on opioids.
- To highlight new evidence regarding the complex effects of opioids on the central and peripheral nervous systems.
- To update understanding of opioid mechanisms, side effects, and clinical utility.
Main Methods:
- Literature review of recent publications on opioid research.
- Analysis of new findings concerning opioid pharmacology and clinical use.
- Synthesis of emerging evidence on opioid's central and peripheral nervous system effects.
Main Results:
- Recent studies continue to reveal the intricate mechanisms of opioid analgesia.
- New data highlight the diverse and complex effects of opioids on both central and peripheral nervous systems.
- Ongoing research provides updated information on opioid side effect profiles and appropriate clinical applications.
Conclusions:
- Understanding of opioid action, side effects, and optimal use is continuously advancing.
- Recent evidence underscores the complexity of opioids, necessitating ongoing research and clinical evaluation.
- This review focuses on the latest findings to inform current and future opioid management strategies.
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