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Updated: Jul 16, 2026

Full-Field Optical Coherence Microscopy for Histology-Like Analysis of Stromal Features in Corneal Grafts
Published on: October 21, 2022
Variant of the big bubble technique in deep anterior lamellar keratoplasty
Pierre Fournié1, François Malecaze, Julien Coullet
1Service d'Ophtalmologie, Hôpital Purpan, Place du Docteur Baylac, 31059 Toulouse Cedex, France. pierrefournie@yahoo.com
Abstract:
We describe a variant of the big-bubble technique that involves placement of a stromal corneal nick and nontraumatic intrastromal insertion of a blunt cannula following anterior lamellar keratectomy. The goal of this technique is to reduce the risk for intraoperative corneal perforation and to obtain a large air bubble between Descemet's membrane and the corneal stroma. Deep anterior lamellar keratoplasty is easier and safer with this technique.

