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Updated: Jul 16, 2026
An Improved Method for Rapid Intubation of the Trachea in Mice
Published on: February 22, 2016
Benefits and risks of mitomycin use in the traumatized tracheal mucosa
Jong-Lyel Roh1, Dong Hyun Kim, Ki Sang Rha
1Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
Objective:
To investigate the efficacy and early complications of mitomycin C (MMC) in tracheal wound models.
Study Design And Setting:
Rabbits (N = 60) were randomized to undergo mucosal injuries to the upper and lower trachea including anterior 120 degrees full thickness (group A, n = 20), anterior 120 degrees partial thickness (group B, 20), and circumferential partial thickness (group C, 20). In each rabbit, the wounds were separately treated with MMC 1.0 mg/mL or saline, and the animals were sacrificed after three weeks.
Results:
Twenty-seven of the 60 animals experienced early death because of tracheal rupture or airway obstruction caused by unresolved scabs on the preinjured tracheal mucosa; the incidence of early death was higher in groups A and C than in group B. In each group, the degree of tracheal stenosis was comparable in wounds treated with MMC and saline.
Conclusion:
These findings suggest that topical MMC has no benefit when used to prevent tracheal stenosis. Acute airway obstruction may occur in MMC-treated rabbits with tracheal wounds.
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