Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

MKK signaling and vascularization.

P E Depeille1, Y Ding, J L Bromberg-White

  • 1Laboratory of Cancer and Developmental Cell Biology, Van Andel Research Institute, 333 Bostwick Avenue, Grand Rapids, MI 49503, USA.

Oncogene
|February 27, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Anthrax Toxin Receptor 1 Is Essential for Arteriogenesis in a Mouse Model of Hindlimb Ischemia.

PloS one·2016
Same author

HIV drug resistance in newly diagnosed adults in a rural prefecture of eastern China.

Epidemiology and infection·2014
Same author

Few-femtosecond time-resolved measurements of X-ray free-electron lasers.

Nature communications·2014
Same author

Expression of Gadd45α in human early placenta and its role in trophoblast invasion.

Placenta·2014
Same author

Observation of a charged charmoniumlike structure in e+ e- → (D* D*)± π∓ at √s = 4.26  GeV.

Physical review letters·2014
Same author

Epidemiological characteristics of motor neuron disease in Chinese patients.

Acta neurologica Scandinavica·2014
Same journal

SRD5A3-mediated aberrant N-glycosylation of SCARA5 promotes ferroptosis in lung adenocarcinoma.

Oncogene·2026
Same journal

Aberrant splicing in human cancer shows possible functional impact on transcription factors.

Oncogene·2026
Same journal

The crosstalk between RNA m6A modification and protein lactylation: emerging insights into tumor progression.

Oncogene·2026
Same journal

Correction: Neuropilin-1 promotes human glioma progression through potentiating the activity of the HGF/SF autocrine pathway.

Oncogene·2026
Same journal

Amphiregulin-mediated EGFR activation drives both intrinsic and acquired resistance to KRAS G12C inhibitors in KRAS G12C-mutant non-small cell lung cancer.

Oncogene·2026
Same journal

Histone lactylation-driven IGF2BP3 promotes intrahepatic cholangiocarcinoma progression via SPP1/CD44-dependent macrophage polarization.

Oncogene·2026
See all related articles

Anthrax lethal factor (LF) inhibits tumor growth by inactivating mitogen-activated protein kinase kinases (MKK). This study reviews evidence that MKK signaling is crucial for tumor vascularization.

Area of Science:

  • Molecular Biology
  • Cancer Research
  • Immunology

Background:

  • Anthrax lethal factor (LF) is a zinc-metalloprotease.
  • LF inactivates mitogen-activated protein kinase kinases (MKK).
  • MKK signaling is implicated in cell proliferation.

Purpose of the Study:

  • To review in vitro and in vivo evidence supporting MKK signaling's role in tumor vascularization.
  • To investigate the impact of LF on tumor vascular content.

Main Methods:

  • Review of existing scientific literature.
  • Comparison of in vitro and in vivo experimental data.

Main Results:

  • LF treatment significantly inhibits tumor growth.

Related Experiment Videos

  • LF treatment leads to a substantial reduction in tumor vascular content.
  • MKK signaling pathways are essential for tumor vascularization.

    • Conclusions:

    • MKK signaling pathways play a critical role in promoting tumor vascularization.
    • The inactivation of MKK by LF has implications for cancer therapy targeting tumor angiogenesis.