Related Experiment Video

Updated: Jul 16, 2026

The Use of Reverse Phase Protein Arrays (RPPA) to Explore Protein Expression Variation within Individual Renal Cell Cancers
12:22

The Use of Reverse Phase Protein Arrays (RPPA) to Explore Protein Expression Variation within Individual Renal Cell Cancers

Published on: January 22, 2013

Identification of deregulated oncogenic pathways in renal cell carcinoma: an integrated oncogenomic approach based on

K A Furge1, M H Tan, K Dykema

  • 1Laboratory of Computational Biology, Van Andel Research Institute, 333 Bostwick Avenue N.E., Grand Rapids, MI 49503, USA. kyle.furge@vai.org.and

Oncogene
|February 27, 2007
PubMed

Insights

Identifying deregulated molecular pathways in kidney cancer subtypes is crucial for targeted therapy. This study uses an oncogenomic approach to link gene expression data with cytogenetic abnormalities for potential diagnostic and therapeutic advancements.

Area of Science:

  • Oncology
  • Genomics
  • Molecular Biology

Background:

  • Kidney cancer comprises diverse histological subtypes, each with unique molecular signatures and deregulated pathways.
  • Specific pathways like VHL/hypoxia in clear cell renal cell carcinoma (RCC) and HGF/Met in papillary RCC are implicated.
  • Understanding these distinct pathways is vital for elucidating tumorigenesis and guiding targeted treatment strategies.

Purpose of the Study:

  • To describe an oncogenomic approach for identifying deregulated molecular pathways in kidney cancer.
  • To integrate gene expression profiling data with cytogenetic abnormalities to pinpoint candidate genes.
  • To explore the potential diagnostic and therapeutic implications of these molecular insights.

Main Methods:

  • Utilized an integrative analysis of gene expression profiling data.
  • Employed an oncogenomic strategy to identify cytogenetic abnormalities and deregulated molecular pathways in RCC.
  • Developed computational models to link predicted pathway abnormalities with cytogenetic findings.

Main Results:

  • The approach successfully identified molecular pathways and cytogenetic abnormalities associated with RCC subtypes.
  • Linked gene expression patterns to specific molecular pathways, offering insights into kidney cancer biology.
  • Established a framework for identifying candidate genes potentially driving tumorigenesis.

Conclusions:

  • The oncogenomic approach provides a powerful tool for molecular research in kidney cancer.
  • Validated computational models hold promise for significant diagnostic and therapeutic advancements.
  • Further research is warranted to validate findings and translate them into clinical applications.

Related Concept Videos

Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
The Retinoblastoma Gene01:20

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...