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Related Experiment Videos

Perseverative error in schizophrenia: correlation with cortical blood flow by SPECT.

M Moreno-Iñiguez1, F Ortuño, R M Bonelli

  • 1Division of Child Psychiatry, Columbia-Presbyterian Hospital & New York State Pschiatric Institute, Columbia University, New York, NY, USA.

Actas Espanolas De Psiquiatria
|February 27, 2007
PubMed
Summary

Schizophrenia patients show altered brain activity patterns, specifically in the right parietal-occipital region, linked to perseverative errors (PE). This regional cortical blood flow (RCBF) pattern may serve as a biological marker for schizophrenia.

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Cognitive Psychology

Background:

  • Perseverative error (PE) is a key symptom and potential phenotypic marker of schizophrenia.
  • Hypofrontality in functional neuroimaging is also a suggested sign of schizophrenia.
  • Combining symptom and sign may reveal a regional cortical blood flow (RCBF) pattern linked to PE, potentially serving as a biological marker.

Purpose of the Study:

  • To investigate the regional cortical blood flow (RCBF) pattern associated with perseverative errors (PE) in schizophrenia.
  • To determine if this RCBF pattern can serve as a biological marker for schizophrenia.
  • To compare brain activity during cognitive tasks between schizophrenia patients and controls.

Main Methods:

  • Single Photon Emission Computerized Tomography (SPECT) was used to measure RCBF.

Related Experiment Videos

  • The Wisconsin Card Sorting Test (WCST) was administered to 18 schizophrenia patients and 13 controls.
  • RCBF was analyzed in five bilateral brain regions, using resting RCBF as a baseline.

    • Main Results:

    • Schizophrenia patients exhibited more PEs than controls on the WCST.
    • A correlation was found between PEs and right occipital RCBF in patients.
    • Controls showed a negative correlation between PEs and left temporal RCBF, and positive correlation for correct responses (CR) with left frontal activity.

    Conclusions:

    • Increased right parietal-occipital activity correlates with PE severity in schizophrenia patients.
    • Left frontal activity is associated with CR in controls, but not in patients.
    • A distinct RCBF redistribution pattern in schizophrenia may represent a phenotypic marker detectable by functional neuroimaging.