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Published on: May 27, 2020
Perseverative error in schizophrenia: correlation with cortical blood flow by SPECT
M Moreno-Iñiguez1, F Ortuño, R M Bonelli
1Division of Child Psychiatry, Columbia-Presbyterian Hospital & New York State Pschiatric Institute, Columbia University, New York, NY, USA.
Actas Espanolas De Psiquiatria
|February 27, 2007
Summary
Schizophrenia patients show altered brain activity patterns, specifically in the right parietal-occipital region, linked to perseverative errors (PE). This regional cortical blood flow (RCBF) pattern may serve as a biological marker for schizophrenia.
Area of Science:
- Neuroscience
- Psychiatry
- Cognitive Psychology
Background:
- Perseverative error (PE) is a key symptom and potential phenotypic marker of schizophrenia.
- Hypofrontality in functional neuroimaging is also a suggested sign of schizophrenia.
- Combining symptom and sign may reveal a regional cortical blood flow (RCBF) pattern linked to PE, potentially serving as a biological marker.
Purpose of the Study:
- To investigate the regional cortical blood flow (RCBF) pattern associated with perseverative errors (PE) in schizophrenia.
- To determine if this RCBF pattern can serve as a biological marker for schizophrenia.
- To compare brain activity during cognitive tasks between schizophrenia patients and controls.
Main Methods:
- Single Photon Emission Computerized Tomography (SPECT) was used to measure RCBF.
- The Wisconsin Card Sorting Test (WCST) was administered to 18 schizophrenia patients and 13 controls.
- RCBF was analyzed in five bilateral brain regions, using resting RCBF as a baseline.
Main Results:
- Schizophrenia patients exhibited more PEs than controls on the WCST.
- A correlation was found between PEs and right occipital RCBF in patients.
- Controls showed a negative correlation between PEs and left temporal RCBF, and positive correlation for correct responses (CR) with left frontal activity.
Conclusions:
- Increased right parietal-occipital activity correlates with PE severity in schizophrenia patients.
- Left frontal activity is associated with CR in controls, but not in patients.
- A distinct RCBF redistribution pattern in schizophrenia may represent a phenotypic marker detectable by functional neuroimaging.
