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Updated: Jul 16, 2026
03:37
Intravitreal Injections in the Ovine Eye
Published on: July 5, 2022
[Retrobulbar optic neuritis associated with Infliximab]
A Bidaguren1, A Müller-Thyssen, A Blanco
1Servicio de Oftalmología, Hospital Donostia, San Sebastián (Guipúzcoa), España. aritzbidaguren@kaixo.com
Archivos De La Sociedad Espanola De Oftalmologia
|February 27, 2007
Summary
Infliximab, a rheumatoid arthritis drug, may cause demyelinating diseases like optic neuritis in older adults. This case highlights a potential link between TNF-alpha inhibitors and neurological side effects.
Area of Science:
- Neurology
- Ophthalmology
- Rheumatology
Background:
- Tumor Necrosis Factor-alpha (TNFa) inhibitors are widely used for autoimmune diseases.
- Rheumatoid arthritis treatment often involves biologic agents like Infliximab.
- Demyelinating diseases can manifest with various neurological symptoms.
Observation:
- A 76-year-old woman experienced sudden vision loss in her left eye.
- The clinical presentation suggested retrobulbar optic neuritis.
- The patient was concurrently undergoing treatment with Infliximab for rheumatoid arthritis.
Findings:
- The patient's age and Infliximab use were noted as potential contributing factors.
- The demyelination observed was suspected to be associated with Infliximab therapy.
- This case suggests a possible link between Infliximab and optic neuritis.
Implications:
- Tumor Necrosis Factor-alpha inhibitors, including Infliximab, are associated with demyelinating conditions.
- Clinicians should consider Infliximab-induced demyelination in patients presenting with optic neuritis.
- Further research is warranted to elucidate the precise mechanisms and incidence of this adverse event.
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