Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Supplemental glucocorticoid therapy.

Katherine D Mieure1, Kelly M Smith, P Shane Winstead

  • 1University of Kentucky Health-Care, Lexington, KY, USA.

Orthopedics
|February 28, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Strategies to Address Communication Vulnerability in Adult Intensive Care Units Through Practice, Environment, and Policy Modifications.

Journal of nursing care quality·2026
Same author

Tegmental kappa-opioid receptor neurons modulate opioid withdrawal via the periaqueductal gray.

Brain : a journal of neurology·2026
Same author

Scoping review of patient and family engagement interventions in diagnosis: a paradox of too much, yet so little.

BMJ quality & safety·2025
Same author

Barriers to and facilitators for implementing a Care Partner program for adult patients with persistent critical illness.

Australian critical care : official journal of the Confederation of Australian Critical Care Nurses·2025
Same author

Reported contributors to communication vulnerability for adult patients in critical care.

Intensive & critical care nursing·2025
Same author

Patient Perspectives on Artificial Intelligence in Health Care: Focus Group Study for Diagnostic Communication and Tool Implementation.

Journal of participatory medicine·2025
Same journal

Preoperative Copper-to-Zinc Ratio and Postoperative Delirium After Hip Fracture Surgery: A Propensity Score-matched Cohort Study.

Orthopedics·2026
Same journal

Supracondylar Distal Femur Fracture Fixation: Early Experiences Comparing the Retrograde Nail With Locking Attachment Washer (LAW) Plate to Traditional Fixation Techniques.

Orthopedics·2026
Same journal

Intra-Articular Vancomycin Powder in Primary Total Knee Arthroplasty: A Retrospective Observational Study.

Orthopedics·2026
Same journal

Limb Salvage Versus Amputation for the Management of Primary Bone Tumors of the Upper Extremity: A Systematic Review.

Orthopedics·2026
Same journal

A Modified Keshishyan Index Demonstrates Three-dimensional Assessment of Asymmetry in Pediatric Pelvic Fractures.

Orthopedics·2026
Same journal

Planned Versus Intraoperative Vascular Surgery Consultations in Orthopedic Oncology.

Orthopedics·2026
See all related articles

Supplemental glucocorticoid therapy remains debated due to diagnostic challenges and variable patient responses. Despite conflicting evidence, cortisol deficiency in critically ill patients may warrant glucocorticoid treatment, necessitating further research.

Area of Science:

  • Endocrinology
  • Critical Care Medicine

Background:

  • Supplemental glucocorticoid therapy is controversial in medicine.
  • Diagnosing cortisol deficiency is challenging due to varied patient presentations and stress responses.
  • Cortisol deficiency in acutely ill patients is linked to increased morbidity and mortality.

Purpose of the Study:

  • To explore the ongoing debate surrounding supplemental glucocorticoid therapy.
  • To highlight the diagnostic difficulties and inter-patient variability in cortisol response.
  • To underscore the importance of continued research in this area.

Main Methods:

  • Review of existing medical literature and clinical guidelines.
  • Analysis of diagnostic challenges and variability in cortisol testing.

Related Experiment Videos

  • Discussion of evidence for and against supplemental glucocorticoid use.

    • Main Results:

    • Diagnosis of cortisol deficiency is often elusive due to diverse clinical signs and symptoms.
    • Defining normal cortisol response during stress is difficult due to significant inter-patient variability.
    • Conflicting evidence exists regarding the benefits of supplemental glucocorticoid treatment.

    Conclusions:

    • Despite diagnostic complexities and debated efficacy, supplemental glucocorticoid therapy is considered when cortisol deficiency is identified in acutely ill patients.
    • There is a consensus on the need for ongoing research to clarify the role of supplemental glucocorticoids.