Verticipyrone, a new NADH-fumarate reductase inhibitor, produced by Verticillium sp. FKI-1083
Hideaki Ui1, Kazuro Shiomi, Hideaki Suzuki
1Kitasato Institute for Life Sciences and Graduate School of Infectious Control Sciences, Kitasato University, Minato-ku, Tokyo 108-8641, Japan.
Abstract:
A new NADH-fumarate reductase inhibitor, verticipyrone, was isolated from the cultured broth of a fungus, Verticillium sp. FKI-1083. The structure was established as (E)-2-methoxy-3,5-dimethyl-6-(3-methyl-2-undecenyl)-4H-pyran-4-one. Verticipyrone exhibited an IC50 value of 0.88 nM against NADH-fumarate reductase of Ascaris suum. Verticipyrone inhibited both Ascaris and bovine heart complex I, and its synthetic analogue, 8,9-dihydro-8-hydroxyverticipyrone, showed good selectivity against Ascaris complex I.
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