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Propofol modulates inner retina function in Beagles
Bertel Kommonen1, Eira Hyvätti, William W Dawson
1Section of Surgery, Department of Clinical Veterinary Medicine, University of Helsinki, Finland. kommonen@mappi.helsinki.fi
Purpose:
To further understand a common veterinary anesthetic, propofol (2,6- di-isopropylphenol) and effects of infusion rates on the retinal neurons in Beagle dogs.
Methods:
Standard full-field blue xenon-flash stimulation elicited responses of dark-adapted eyes, which were recorded from dogs before and after a propofol infusion rate increase.
Results:
Electroretinogram b-waves increased significantly after the infusion rate increase and decreased with decline (P < 0.0001). Also, a weak significance (P = 0.041) for a-wave peak amplitude increase was found after infusion rate increase. The initial part (first 18 ms) of the leading edge of the a-wave remained unchanged. No significant differences in times to a- and b-wave peaks were found.
Conclusion:
Enhanced b-wave response and decline is due to sensitivity of postreceptoral cells, possibly interplexiform and amacrine cells, to propofol concentration.
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