Related Experiment Video
Updated: Aug 10, 2026
07:44
Retroductal Submandibular Gland Instillation and Localized Fractionated Irradiation in a Rat Model of Salivary Hypofunction
Published on: April 24, 2016
Mandibular growth and tooth eruption after localized x-radiation
A M Ubios1, M J Piloni, R L Cabrini
1Department of Pathology, Faculty of Dentistry, University of Buenos Aires, Argentina.
Summary
Localized x-radiation significantly hinders mandibular bone growth and molar eruption in rats. Histologic findings reveal damage, suggesting caution during radiotherapy planning in children.
Area of Science:
- Oral and Maxillofacial Surgery
- Developmental Biology
- Radiation Oncology
Background:
- Radiotherapy, particularly in children, can impact craniofacial development.
- Understanding the specific effects of radiation on mandibular growth is crucial for mitigating long-term consequences.
Purpose of the Study:
- To evaluate the morphometric effects of localized x-radiation on mandibular bone growth.
- To assess the impact of x-radiation on molar eruption and root development.
Main Methods:
- Growing rats received a localized dose of 20 Gy x-radiation to the molar zone.
- Morphometric analysis of mandibular length, height, and molar eruption parameters was performed using lateral radiographs.
- Histologic examination of irradiated tissues was conducted at 30 and 60 days postirradiation.
Main Results:
- Experimental animals showed significantly reduced mandibular length and height compared to controls.
- Molar eruption was delayed or inhibited, with findings of odontoblastic atrophy and alveolodentary ankylosis.
- Root formation was severely impaired, and osteodentin was observed in ankylosed areas.
Conclusions:
- Localized x-radiation adversely affects mandibular growth and tooth eruption in a developing rodent model.
- These findings highlight the potential for significant craniofacial alterations following radiotherapy and underscore the need for careful treatment planning in pediatric patients.
