Efficacy of the de novo-derived antimicrobial peptide WLBU2 against oral bacteria
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Updated: Jul 16, 2026

Antimicrobial Peptides Produced by Selective Pressure Incorporation of Non-canonical Amino Acids
Published on: May 4, 2018
Karen F Novak1, William J Diamond, Sreenatha Kirakodu
1Center for Oral Health Research, 414 Health Sciences Research Building, University of Kentucky, Lexington, KY 40536-0305, USA. knova2@uky.edu
Abstract:
The efficacy of a novel synthetic antimicrobial peptide (WLBU2) was evaluated against three oral microorganisms (grown planktonically): Streptococcus gordonii, Fusobacterium nucleatum, and Porphyromonas gingivalis. WLBU2 killed all three species, with F. nucleatum being the most susceptible. WLBU2 also reduced the bacterial burden of S. gordonii and F. nucleatum biofilms.
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