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Typical heart performance is influenced by heart rate, rhythm, myocardial contraction, and metabolism or blood flow. The cardiac muscle exhibits distinct electrophysiological features, including pacemaker activity and calcium channel control, which play a vital role in the heart's response to various drugs. The autonomic nervous system, comprising the sympathetic and parasympathetic branches, regulates heart rate. Sympathetic activation increases heart rate, while parasympathetic activation...

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Electrocardiogram

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Related Experiment Video

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Cardiac Catheterization in Mice to Measure the Pressure Volume Relationship: Investigating the Bowditch Effect

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CT of cardiac function.

Giancarlo Savino¹, Peter Zwerner, Christopher Herzog

¹Radiology Department, Catholic University, Policlinico Gemelli, Rome.

Journal of Thoracic Imaging

|February 28, 2007

Summary

Multidetector computed tomography (MDCT) offers promising results for diagnosing coronary artery disease and assessing heart ventricle function. Advanced MDCT can now evaluate regional contractility and right ventricle function, expanding its clinical use.

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Area of Science:

Cardiovascular Imaging
Radiology
Medical Diagnostics

Background:

Multidetector computed tomography (MDCT) shows potential in diagnosing coronary artery disease.
MDCT can assess global function of the left ventricle (LV) and right ventricle, correlating well with standard methods.
Recent advancements enable regional LV contractility assessment using MDCT.

Purpose of the Study:

To evaluate the role of MDCT in diagnosing coronary artery disease.
To assess the capability of MDCT in evaluating global and regional left and right ventricle function.
To explore the clinical applicability of MDCT in cardiac imaging.

Main Methods:

Utilizing multidetector computed tomography (MDCT) with advanced scanners.
Employing specific postprocessing software for MDCT function evaluation.
Analyzing 2D and 3D cine-loop models for qualitative and quantitative assessment.
Performing high-resolution 3D reconstructions throughout the cardiac cycle.

Main Results:

MDCT demonstrates good initial correlation with standard modalities for LV and RV function.
Regional LV contractility can be assessed both qualitatively and quantitatively.
MDCT provides functional information for the right ventricle, valuable in conditions like pulmonary embolism and congenital heart disease.

Conclusions:

MDCT is a valuable tool for coronary artery disease diagnosis and cardiac function assessment.
The ability to evaluate regional contractility and right ventricle function enhances MDCT's clinical utility.
Promising accuracy results suggest a rapid increase in the clinical application of MDCT for cardiac imaging.