Related Experiment Video

Updated: Jul 16, 2026

Genotypic Inference of HIV-1 Tropism Using Population-based Sequencing of V3
11:10

Genotypic Inference of HIV-1 Tropism Using Population-based Sequencing of V3

Published on: December 27, 2010

The relationship between methamphetamine and popper use and risk of HIV seroconversion in the multicenter AIDS cohort

Michael W Plankey1, David G Ostrow, Ron Stall

  • 1Department of Medicine, Division of Infectious Diseases, Georgetown University Medical Center, Washington, DC 20007, USA. mwp23@georgetown.edu

Journal of Acquired Immune Deficiency Syndromes (1999)
|February 28, 2007
PubMed
Abstract

Insights

Methamphetamine and popper use significantly increase HIV seroconversion risk in men who have sex with men (MSM). Higher numbers of unprotected receptive anal sex partners also elevate risk, especially when combined with drug use.

Area of Science:

  • Epidemiology
  • Public Health
  • Infectious Disease Research

Background:

  • Investigating the link between methamphetamine use and HIV seroconversion in men who have sex with men (MSM).
  • Utilizing longitudinal data from the Multicenter AIDS Cohort Study (MACS).

Purpose of the Study:

  • To examine the association between methamphetamine use and HIV seroconversion among MSM.
  • To assess the impact of concurrent drug use and sexual behaviors on HIV risk.

Main Methods:

  • Analysis of longitudinal data from 4003 HIV-seronegative MSM enrolled between 1984-2003.
  • Assessing recent methamphetamine, popper, and other drug use, alongside sexual behaviors and depression symptoms.
  • Time to HIV seroconversion was the primary outcome, adjusted for multiple covariates.

Main Results:

  • Methamphetamine use was associated with a 1.46-fold increased hazard of HIV seroconversion.
  • Popper use showed a 2.10-fold increased hazard.
  • Increased unprotected receptive anal sexual partners significantly elevated HIV risk, with a joint hazard of 3.05 for combined methamphetamine and popper use.

Conclusions:

  • Synergistic effects of drug use and sexual risk behaviors heighten HIV seroconversion rates in MSM.
  • Further research into these mechanisms is crucial for developing targeted HIV prevention strategies.
  • Focus on non-monogamous, drug-using MSM populations for effective interventions.

More Related Videos

A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration09:16

A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration

Published on: January 22, 2016

Related Concept Videos

Amebiasis01:28

Amebiasis

Entamoeba histolytica, a protozoan parasite, is responsible for intestinal and extraintestinal amebiasis. Though a significant proportion of infections remain asymptomatic, approximately 50 million individuals annually are estimated to present with clinical disease, resulting in up to 100,000 deaths globally. The disease burden is disproportionately high in regions with lower socioeconomic status, such as parts of India, Africa, Mexico, and Latin America.Etiology and TransmissionThe infective...
Retrovirus Life Cycles01:10

Retrovirus Life Cycles

Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the retrovirus to...
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast, controlled...
Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Therapeutic Drug Monitoring: Affecting Factors01:29

Therapeutic Drug Monitoring: Affecting Factors

Therapeutic Drug Monitoring (TDM) is the clinical practice of measuring specific drug levels in a patient's blood or body tissues to manage and optimize therapy. TDM is crucial for drugs with narrow therapeutic windows, like warfarin and phenytoin, where incorrect doses can lead to treatment failure or severe side effects. This monitoring ensures the dosage administered is within a safe and effective range. The factors affecting therapeutic drug monitoring include:Patient-Specific Factors:a.
Analysis of Population Pharmacokinetic Data01:12

Analysis of Population Pharmacokinetic Data

Analysis of population pharmacokinetic data involves studying the behavior of drugs within diverse populations to understand their pharmacokinetic parameters. Traditional pharmacokinetic methods typically involve collecting samples from a few individuals and estimating these parameters. While these methods are commonly used, they have limitations in capturing the variability in drug response among individuals or heterogeneous populations. Population pharmacokinetics is employed to address these...