Related Experiment Video

Updated: Jul 16, 2026

A Catheter-Related Candida albicans Infection Model in Mouse
03:24

A Catheter-Related Candida albicans Infection Model in Mouse

Published on: March 22, 2024

Postrenal azotemia due to C. albicans pyocystitis and a Candidal plug

Douglas P Olson1, Dragica K Mrkoci

  • 1George Washington University School of Medicine, Washington, DC 20422, USA.

Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
|February 28, 2007
PubMed
Abstract

Insights

A rare fungal infection caused a urinary blockage, leading to acute renal failure (ARF). Prompt treatment with fluconazole resolved the obstruction and restored kidney function, highlighting the importance of considering infectious causes of post-renal azotemia.

Area of Science:

  • Nephrology
  • Infectious Diseases
  • Urology

Background:

  • Acute renal failure (ARF) can stem from various causes, categorized as pre-renal, intrarenal, or post-renal.
  • Post-obstructive etiologies account for a small fraction of ARF cases.
  • Infectious causes of post-obstructive azotemia are exceptionally rare but warrant consideration.

Observation:

  • A hospitalized patient presented with acute renal failure.
  • Examination revealed a candidal plug obstructing the urethral meatus.
  • Significant purulent material was found in bladder washings.

Findings:

  • The patient's acute renal failure was attributed to infectious post-obstructive pyocystitis and a urethral candidal plug.
  • Treatment with fluconazole successfully addressed the Candida albicans infection.
  • Urinary retention and bilateral hydronephrosis were resolved.

Implications:

  • Resolution of the candidal plug and antifungal treatment led to the return of baseline renal function.
  • This case underscores the necessity of considering infectious etiologies in post-renal azotemia.
  • Early diagnosis and targeted treatment are crucial for managing rare causes of ARF.

More Related Videos

Implementing Patch Clamp and Live Fluorescence Microscopy to Monitor Functional Properties of Freshly Isolated PKD Epithelium08:46

Implementing Patch Clamp and Live Fluorescence Microscopy to Monitor Functional Properties of Freshly Isolated PKD Epithelium

Published on: September 1, 2015

Related Concept Videos

Acute Pyelonephritis I: Introduction01:27

Acute Pyelonephritis I: Introduction

Pyelonephritis is a bacterial infection that primarily affects the renal parenchyma and collecting system, including the renal pelvis, tubules, and interstitial tissue of one or both kidneys. It can be classified as either acute—a sudden, severe infection—or chronic, which refers to long-term or recurrent kidney infections.The primary cause of acute pyelonephritis (APN) is bacterial infection, with Escherichia coli accounting for approximately 70-80% of cases. Other bacteria, such as Proteus,...
Acute Pyelonephritis II: Diagnostic Studies and Management01:28

Acute Pyelonephritis II: Diagnostic Studies and Management

Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...
Urinary Tract Infection II: Pathophysiology01:25

Urinary Tract Infection II: Pathophysiology

The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care01:30

Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care

A healthcare provider can diagnose a urinary tract infection (UTI) through several methods:Medical History and Symptoms: The provider will take a detailed medical history and ask about symptoms such as frequent urination, burning sensation during urination, and lower abdominal pain.Urinalysis: A clean-catch urine sample is collected in a sterile container and tested for the presence of bacteria, white blood cells (leukocytes), nitrites, blood, and protein. The presence of leukocytes and...