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Published on: August 11, 2023
Expression of Bcl-2 on oral cavity pathologies
Iwona Niedzielska1, Daniel Sypnilewski, Zbigniew Niedzielski
1Department of Maxillofacial Surgery, Medical University of Silesia, Katowice, Poland. stomgab@wp.pl
Summary
Monitoring BCL-2 gene expression in oral cavity tissues can help predict the severity of hyperplasia. Significant differences were found between carcinoma, neoplasm in situ malignancies, and healthy tissue.
Area of Science:
- Oral pathology
- Molecular biology
- Cancer research
Background:
- Oral pathologies are traditionally diagnosed using histochemical analysis.
- Molecular analysis offers a future diagnostic avenue, with the BCL-2 gene being a potential marker of interest.
Purpose of the Study:
- To investigate the role and expression patterns of the BCL-2 gene in various oral cavity pathologies.
- To correlate BCL-2 expression with histopathological findings and biopsy site.
Main Methods:
- Molecular analysis of BCL-2 expression in 45 oral cavity tumor patients.
- Biopsies collected from incision lines, tumor sections, and healthy tissues.
- Comparison of BCL-2 expression across hyperplasia, neoplasm in situ malignancy, and carcinoma groups.
Main Results:
- No significant difference in BCL-2 expression was observed among different hyperplasia subgroups.
- Statistically significant differences in BCL-2 expression were found between the main pathological groups (p=0.00002) and biopsy sites (p=0.002).
- The most pronounced differences in BCL-2 expression were between carcinoma and incision line tissues.
Conclusions:
- BCL-2 expression levels vary significantly across different stages of oral cavity malignancy.
- Monitoring BCL-2 expression may aid in prognostic assessment of oral cavity hyperplasias and their progression.
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