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Related Experiment Videos

Mucormycosis in trauma patients.

C S Cocanour1, P Miller-Crotchett, R L Reed

  • 1Department of Surgery, University of Texas Medical School Houston.

The Journal of Trauma
|January 1, 1992
PubMed
Summary

Cutaneous mucormycosis is a rare, fatal infection in trauma patients. Early diagnosis and treatment, including aggressive debridement and amphotericin B, are crucial for survival.

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Area of Science:

  • Infectious Diseases
  • Trauma Surgery
  • Dermatology

Background:

  • Cutaneous mucormycosis is a rare fungal infection.
  • It poses a significant mortality risk, particularly in trauma patients.
  • Risk factors include open wounds, underlying conditions, and immunosuppression.

Purpose of the Study:

  • To review the clinical experience with cutaneous mucormycosis in trauma patients.
  • To identify risk factors, clinical presentations, and outcomes.
  • To emphasize the importance of prompt diagnosis and treatment.

Main Methods:

  • Retrospective review of 11 trauma patients with biopsy- or culture-proven cutaneous mucormycosis over 9 years.
  • Analysis of patient demographics, injury types, wound characteristics, and treatment outcomes.

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  • Comparison of clinical features between survivors and non-survivors.

    • Main Results:

    • Eleven trauma patients (9 blunt trauma, 2 severe burns) developed mucormycosis.
    • All patients had open wounds; none had pre-existing risk factors for immunosuppression.
    • Mortality was 36% (4/11); non-survivors had head/trunk involvement, while survivors had extremity-only involvement.

    Conclusions:

    • Trauma patients are at risk for mucormycosis due to factors like open wounds and iatrogenic immunosuppression.
    • Prompt diagnosis, aggressive surgical debridement, and parenteral amphotericin B are essential for successful treatment.
    • Clinical presentation (location of infection) may predict patient outcomes.