Hemostatic changes in thyroid diseases: haemostasis and thrombosis

Area of Science:

• Endocrinology
• Hematology
• Internal Medicine

Background:

• Thyroid dysfunction is linked to hemostatic abnormalities, including bleeding and thrombosis.
• Thyroid hormones influence the synthesis of hemostatic factors and immune function.

Purpose of the Study:

• To review the relationship between thyroid disorders and hemostasis.
• To discuss primary hemostasis, coagulation factors, and the fibrinolytic system in thyroid disease.

Main Methods:

• Literature review of recent studies.
• Analysis of data on thyroid disorders and hemostasis.

Main Results:

• Thyroid disorders cause coagulation abnormalities through direct hormone effects or immune derangement.
• Hyperthyroid patients exhibit a hypercoagulable state.
• Moderate hypothyroidism increases thrombosis risk, while severe hypothyroidism is associated with bleeding.

Conclusions:

• Thyroid hormones directly affect hemostatic factor synthesis.
• Immune function derangements contribute to hemostatic abnormalities in thyroid disease.
• Clinical presentation of hemostatic issues varies with thyroid dysfunction severity.