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Omeprazole in post-gastrocystoplasty metabolic alkalosis and aciduria
T J Kinahan1, A E Khoury, G A McLorie
1Department of Urology, Hospital for Sick Children, Toronto, Ontario, Canada.
The Journal of Urology
|February 1, 1992
Abstract:
The use of segments of stomach for bladder augmentation is gaining popularity in pediatric urology due to favorable muscular and secretory properties. However, in a renal failure patient who underwent gastrocystoplasty a high level of acid production within the bladder associated with persistent hypergastrinemia was noted leading to severe systemic metabolic alkalosis. This condition was unresponsive to standard acid-inhibiting or neutralizing therapies but it was treated successfully with omeprazole, a proton-pump inhibitor recently introduced for treatment of peptic ulcer disease.