Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Gastroesophageal Reflux Disease01:25

Gastroesophageal Reflux Disease

Gastroesophageal reflux disease (GERD) is the backward flow of stomach contents (acid, pepsin, or bile) into the esophagus, causing mucosal inflammation known as esophagitis. It results from failure of antireflux mechanisms, mainly the lower esophageal sphincter (LES), influenced by mechanical and physiological factors.Etiology and Risk FactorsGERD develops when LES function is weakened or when intra-abdominal pressure increases. Risk factors include aging, obesity, and sliding hiatal hernia,...
Gastroesophageal Reflux Disease II: Clinical Features and Management01:29

Gastroesophageal Reflux Disease II: Clinical Features and Management

Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
Gastroesophageal Reflux Disease I: Meaning and Pathophysiology01:29

Gastroesophageal Reflux Disease I: Meaning and Pathophysiology

Gastroesophageal Reflux Disease (GERD) involves the recurrent backflow of the stomach or duodenal contents into the esophagus, leading to troublesome symptoms and potential esophageal mucosal damage. Although GERD is often referred to as a disease, it is more accurately described as a syndrome, as it encompasses a range of symptoms and complications rather than a singular pathological entity, impacting a large number of individuals as the most prevalent upper gastrointestinal problem. Roughly...
Esophageal Strictures-I: Introduction01:30

Esophageal Strictures-I: Introduction

Esophageal strictures involve abnormal narrowing or tightening of the esophagus. They vary in length and severity, ranging from mild constriction to complete obstruction, and are classified as benign (noncancerous) or malignant (cancerous).
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
Barrett Esophagus-II: Clinical Manifestations and Management01:21

Barrett Esophagus-II: Clinical Manifestations and Management

Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure entails...
Esophageal Strictures-II: Clinical Features and Management01:26

Esophageal Strictures-II: Clinical Features and Management

Patients with esophageal strictures often experience a range of symptoms. Initially, they may have difficulty swallowing solid foods, which can progress to include liquids. Additional symptoms may involve chest pain or discomfort, regurgitating food and fluids, heartburn, unintentional weight loss, coughing or choking during meals, and hoarseness.
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Gastroesophageal reflux disease and dyspepsia--drug therapy].

Praxis·2006
Same author

[Gastroesophageal reflux disease].

Praxis·2005
Same author

[Pancreatic carcinoma--symptoms and diagnostic procedure].

Praxis·2005
Same author

[Tumors of the small intestine].

Praxis·2002
Same author

["Ultrasonographically detected liver lesion"--how to proceed?].

Praxis·2000
Same author

[Gastroesophageal reflux disease--extraesophageal manifestations].

Praxis·1998

Related Experiment Video

Updated: Jul 16, 2026

Simultaneous Laryngopharyngeal and Conventional Esophageal pH Monitoring
06:46

Simultaneous Laryngopharyngeal and Conventional Esophageal pH Monitoring

Published on: December 14, 2020

[Gastroesophageal reflux disease--update 2006].

H Gräter1

  • 1Klinik für Onkologie, Gastroenterologie und Allgemeine Innere Medizin, Klinikum Esslingen.

Praxis
|March 1, 2007
PubMed
Summary

Gastroesophageal Reflux Disease (GERD) management varies by age and symptom presentation. Proton pump inhibitors are primary treatments, with surgery as an option for some, and surveillance recommended for Barrett

Area of Science:

  • Gastroenterology
  • Internal Medicine

Context:

  • Gastroesophageal Reflux Disease (GERD) presents a wide spectrum of illness, from mild symptoms to severe complications.
  • Diagnostic and treatment strategies for GERD differ significantly based on patient demographics and symptom characteristics.

Purpose:

  • To outline current diagnostic and therapeutic approaches for Gastroesophageal Reflux Disease (GERD).
  • To emphasize the importance of endoscopic evaluation in specific patient populations.
  • To highlight the role of pharmacotherapy and surgical interventions in GERD management.

Summary:

  • Younger patients with typical GERD symptoms may not require initial endoscopy.
  • Esophagogastroscopy is crucial for elderly patients and those with atypical GERD symptoms.
  • Proton pump inhibitors (PPIs) are the first-line pharmacotherapy for GERD symptom relief.

More Related Videos

Surgical Models of Gastroesophageal Reflux with Mice
05:19

Surgical Models of Gastroesophageal Reflux with Mice

Published on: August 25, 2015

Related Experiment Videos

Last Updated: Jul 16, 2026

Simultaneous Laryngopharyngeal and Conventional Esophageal pH Monitoring
06:46

Simultaneous Laryngopharyngeal and Conventional Esophageal pH Monitoring

Published on: December 14, 2020

Surgical Models of Gastroesophageal Reflux with Mice
05:19

Surgical Models of Gastroesophageal Reflux with Mice

Published on: August 25, 2015

  • Anti-reflux surgery offers an effective alternative for select individuals.
  • Endoscopic treatment options for GERD are still under development.
  • Surveillance for Barrett's esophagus, a precancerous lesion, is recommended.

    • Impact:

    • Provides a concise overview of GERD management, aiding clinicians in decision-making.
    • Underscores the need for personalized diagnostic and treatment plans for GERD patients.
    • Informs about the long-term implications of GERD, including the risk of Barrett's esophagus.