Related Experiment Video
Updated: Jul 10, 2026

11:14
Ex Vivo Infection of Human Lymphoid Tissue and Female Genital Mucosa with Human Immunodeficiency Virus 1 and Histoculture
Published on: October 12, 2018
Effect of HIV posttest counseling on STD incidence
J M Zenilman1, B Erickson, R Fox
1Johns Hopkins University School of Medicine, Division of Infectious Diseases, Baltimore, Md.
JAMA
|February 12, 1992
Summary
Human immunodeficiency virus (HIV) testing and counseling did not significantly reduce subsequent sexually transmitted diseases (STDs). Both HIV-positive and HIV-negative patients had high rates of repeat STDs, highlighting a public health challenge.
Area of Science:
- Public Health
- Infectious Diseases
- Behavioral Science
Background:
- Human immunodeficiency virus (HIV) testing and counseling are crucial public health interventions.
- Understanding the impact of these interventions on subsequent high-risk behaviors, such as sexually transmitted diseases (STDs), is essential for effective prevention strategies.
Purpose of the Study:
- To evaluate the effectiveness of HIV testing and posttest counseling in reducing subsequent high-risk behaviors, specifically the incidence of STDs.
- To compare STD incidence in HIV-seropositive versus HIV-seronegative patients after testing and counseling.
Main Methods:
- A chart review was conducted on 868 HIV-seropositive and 1104 HIV-seronegative patients at a public STD clinic.
- Patients were matched by age, sex, and HIV test month and observed for incident STDs over 6-23 months post-counseling.
- STD diagnoses were classified hierarchically after notification of HIV test results and receipt of posttest counseling.
Main Results:
- While 71% of HIV-seropositive and 63% of HIV-seronegative patients returned for counseling, significant rates of repeat STDs were observed in both groups.
- HIV-seropositive patients had a 3.9% rate of probable STDs compared to 10.2% in HIV-seronegative patients (P < .001).
- A higher proportion of HIV-seronegative patients (3.3%) than HIV-seropositive patients (1.5%) reported an STD-infected sexual partner (P < .03).
Conclusions:
- Both HIV-seropositive and HIV-seronegative individuals exhibited high rates of repeat STDs following posttest counseling.
- These findings underscore a significant public health challenge in developing effective strategies to prevent high-risk behaviors and reduce STD transmission.
Related Concept Videos
Retrovirus Life Cycles
Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the retrovirus to...
Sexually Transmitted Infections
Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
Pulmonary Tuberculosis I
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Genital Herpes
Genital herpes is a sexually transmitted infection primarily caused by herpes simplex virus type 2 (HSV-2), though herpes simplex virus type 1 (HSV-1) is increasingly implicated in genital infections, particularly among younger populations. Transmission occurs mainly through sexual contact, with asymptomatic viral shedding serving as a major route of spread. This characteristic makes HSV-2 difficult to control at a population level, as individuals may unknowingly transmit the virus even in the...
Amebiasis
Entamoeba histolytica, a protozoan parasite, is responsible for intestinal and extraintestinal amebiasis. Though a significant proportion of infections remain asymptomatic, approximately 50 million individuals annually are estimated to present with clinical disease, resulting in up to 100,000 deaths globally. The disease burden is disproportionately high in regions with lower socioeconomic status, such as parts of India, Africa, Mexico, and Latin America.Etiology and TransmissionThe infective...
Trichomoniasis
Trichomonas vaginalis is a flagellated protozoan parasite and the causative agent of trichomoniasis, one of the most prevalent non-viral sexually transmitted infections in the United States. This extracellular parasite primarily colonizes the lower genitourinary tract in women—particularly the vagina—and in men, the urethra and prostate. Its structural and functional adaptations enable its survival, motility, and pathogenicity within the host environment.Structural Features and Host EntryT.

