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Updated: Jul 16, 2026

Coulomb Explosion Imaging as a Tool to Distinguish Between Stereoisomers
Published on: August 18, 2017
Interchain-solvent-induced chirality change of 1D helical chains: from achiral to chiral crystallization
Long Jiang1, Xiao-Long Feng, Cheng-Yong Su
1MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, State Key Laboratory of Optoelectronic Materials and Technologies, Instrumentation Analysis & Research Center, Sun Yat-Sen University, Guangzhou 510275, China.
Abstract:
Three helical supramolecular stereoisomers of meso-2, Delta-2, and Delta-3 with the formula of cis-[Ni(f-rac-L)][Ni(CN)4] were successfully constructed based on the [Ni(f-rac-L)2+ and [Ni(CN)4]2- building blocks (L = 5,5,7,12,12,14-hexamethyl-1,4,8,11-tetraazacyclotetradecane). In all three supramolecular stereoisomers, cis-[Ni(f-rac-L)]2+ cations are alternately bridged by [Ni(CN)4]2- anions through two cis (in meso-2 and Delta-2) or trans (in Delta-3) cyano groups to form one-dimensional (1D) helical chains of cis-[Ni(f-rac-L)][Ni(CN)4]. In meso-2, the right/left-handed chirality of the originally formed chain is transferred oppositely to adjacent chains through the interchain hydrogen-bonding interactions of hexameric water clusters, leading to the formation of meso-2 with a central symmetrical space group, P21/n, in which the 1D helical chains are packed in an alternating right- and left-handed chirality. In Delta-2 and Delta-3, the right/left-handed chirality of the original chain is transferred uniformly to adjacent chains through the zipper-like interchain hydrophobic interactions, resulting in the formation of Delta-2 and Delta-3 with chiral space groups of P212121 and P3121, respectively, in which all of the 1D helical chains are arranged in the same right/left-handed chirality.
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