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Protein glycation: effects upon protein recognition by the proximal tubule
A Kowluru1, R A Kowluru, S Solomon
1Life Sciences Division, Los Alamos National Laboratory, University of California, New Mexico 87545.
Life Sciences
|January 1, 1992
Abstract:
Reabsorption of 125I labeled unmodified and glycated albumin by the proximal tubule was studied using micropuncture technique in wistar rats of different ages. The data show a significant reabsorption of unmodified albumin while the glycated albumin was virtually excluded from reabsorption process. Among different explanations considered, we think molecular charge of the protein seems to be a key factor for the altered recognition of glycated albumin by the proximal tubule.