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Related Experiment Videos

Peripapillary atrophy after acute primary angle closure.

Kelvin Y C Lee1, Florian Rensch, Tin Aung

  • 1Glaucoma Department, Singapore National Eye Centre, 11 Third Hospital Avenue, Singapore 168751.

The British Journal of Ophthalmology
|March 1, 2007
PubMed
Summary

Peripapillary atrophy zones (alpha and beta) showed no significant enlargement after acute primary angle closure (APAC). However, the optic cup did enlarge over a four-month follow-up period in these patients.

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Area of Science:

  • Ophthalmology
  • Glaucoma Research
  • Optic Nerve Studies

Background:

  • Acute primary angle closure (APAC) is a medical emergency that can lead to vision loss.
  • The effects of APAC on the optic nerve head, specifically peripapillary atrophy, require further investigation.
  • Understanding structural changes post-APAC is crucial for managing glaucoma risk.

Purpose of the Study:

  • To investigate the morphometric changes in peripapillary atrophy (alpha and beta zones) following acute primary angle closure (APAC).
  • To assess the long-term impact of APAC on the optic nerve head structure over a four-month period.

Main Methods:

  • Prospective observational study involving 40 eyes from 38 patients of Chinese ethnicity experiencing APAC.
  • Laser iridotomy was performed to normalize intraocular pressure in all participants.

Related Experiment Videos

  • Morphometric analysis of optic disc photographs at 2 and 16 weeks post-APAC, focusing on alpha and beta zones of peripapillary atrophy.

    • Main Results:

    • No significant changes were observed in the minimum or maximum widths of the alpha and beta zones of peripapillary atrophy at 16 weeks compared to baseline.
    • A statistically significant increase in the mean cup-to-disc ratio was noted at the end of the four-month follow-up (p<0.0001).

    Conclusions:

    • The study indicates that the alpha and beta zones of peripapillary atrophy do not significantly enlarge after an episode of APAC.
    • Despite stable peripapillary atrophy, an enlargement of the optic cup occurs post-APAC, suggesting potential optic nerve damage.
    • These findings highlight the importance of monitoring optic nerve changes even when atrophy zones appear stable after angle closure events.