Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Collagen fragments modulate innate immunity.

Amelia H Thomas1, Elazer R Edelman, Collin M Stultz

  • 1The Computer Science and Artificial Intelligence Laboratory, Cambridge, Massachusetts 02139, USA.

Experimental Biology and Medicine (Maywood, N.J.)
|March 1, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cardiorenal Hemodynamic Coupling: Mechanical Circulatory Support Augments Renal Blood Flow via Renal Vasodilation.

JACC. Basic to translational science·2026
Same author

Flow-mediated endothelial remodeling and inflammation drive developmental vascular susceptibility in ldlr loss of function.

Nature communications·2026
Same author

Toward Smart and Adaptive Endovascular Devices: The Role of Digital Twins in Precision Vascular Medicine.

Interventional cardiology clinics·2026
Same author

Endovascular Drug Delivery from Stents and Balloons in Peripheral Arteries: What Every Interventionalist Must Know.

Interventional cardiology clinics·2026
Same author

Forecasting left ventricular systolic dysfunction in heart failure with artificial intelligence.

EClinicalMedicine·2026
Same author

3D endothelial cell scaffolds protect liver explants and exhibit therapeutic effects on liver fibrosis.

JHEP reports : innovation in hepatology·2026
Same journal

Nicotinamide adenine dinucleotide phosphate oxidase 4 in lung disease: a review of its biology and therapeutic potential.

Experimental biology and medicine (Maywood, N.J.)·2026
Same journal

Phenotypic profiling of Pathogen Box compounds MMV667494 and MMV028694 in bloodstream-form <i>Trypanosoma brucei brucei</i>.

Experimental biology and medicine (Maywood, N.J.)·2026
Same journal

High systolic blood pressure and stroke: evidence from the NHANES 1999-2023 and global burden of disease 2021.

Experimental biology and medicine (Maywood, N.J.)·2026
Same journal

Scaling human liver microphysiological systems: implementing a higher-throughput liver acinus microphysiological system platform.

Experimental biology and medicine (Maywood, N.J.)·2026
Same journal

Race, oxygen exposure, and retinopathy of prematurity: re-examining a persistent epidemiologic paradox.

Experimental biology and medicine (Maywood, N.J.)·2026
Same journal

Peripheral immune cells and glycation indices as potential diagnostic biomarkers in amyotrophic lateral sclerosis.

Experimental biology and medicine (Maywood, N.J.)·2026
See all related articles

Collagen fragments can modulate inflammation by affecting interleukin-1 beta (IL-1β) production in monocytes. This finding is crucial for understanding collagen

Area of Science:

  • Biochemistry
  • Immunology
  • Molecular Biology

Background:

  • Inflammation is implicated in diseases like rheumatoid arthritis and atherosclerosis.
  • Proinflammatory cytokines drive collagenolysis (collagen breakdown).
  • The impact of collagen fragments on inflammation is not well understood.

Purpose of the Study:

  • To investigate how collagen fragments influence the inflammatory response.
  • To determine if collagen degradation products affect cytokine production.

Main Methods:

  • Human peripheral-blood monocytes were utilized.
  • The effect of various collagen fragments on IL-1beta production was measured.

Main Results:

  • Different collagen fragments demonstrated the ability to either increase or decrease IL-1beta production.

Related Experiment Videos

  • This suggests a regulatory role for collagen-derived peptides in inflammation.

    • Conclusions:

    • Collagen degradation produces peptides that can modulate the innate immune response.
    • Amino acid variations in collagen may significantly impact disease pathogenesis.