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Related Experiment Videos

Peripheral sensory abnormalities in patients with multiple sclerosis.

J M Shefner1, J L Carter, C Krarup

  • 1Neurophysiology Laboratories, Brigham and Women's Hospital, Boston, MA 02115.

Muscle & Nerve
|January 1, 1992
PubMed
Summary

Multiple sclerosis (MS) may cause mild peripheral nervous system myelin defects. Near nerve studies revealed reduced minimum conduction velocity and altered supernormal periods in MS patients, suggesting peripheral myelin involvement.

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Area of Science:

  • Neurology
  • Neuroscience
  • Peripheral Nervous System

Background:

  • Multiple sclerosis (MS) is primarily a central nervous system (CNS) disease affecting myelin.
  • Emerging evidence suggests potential mild peripheral nervous system (PNS) myelin involvement in MS.
  • Understanding PNS involvement is crucial for a comprehensive view of MS pathology.

Purpose of the Study:

  • To investigate potential mild deficits in peripheral myelin in patients with multiple sclerosis.
  • To evaluate electrophysiological parameters of the sural nerve in MS patients.
  • To compare findings in MS patients with a control sample.

Main Methods:

  • Performed near nerve electrophysiological studies on the sural nerves of 14 patients diagnosed with multiple sclerosis.

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  • Measured peak-to-peak amplitude and maximum conduction velocity of sensory action potentials.
  • Assessed minimum conduction velocity and the amplitude of the supernormal period, comparing with a control group.

    • Main Results:

    • Normal peak-to-peak amplitude and maximum conduction velocity were observed in 9 out of 14 MS patients.
    • Abnormal reduction in minimum conduction velocity (slowest conducting component) was found in 9 MS patients.
    • A significant reduction in the amplitude of supernormality was detected in MS patients compared to controls.

    Conclusions:

    • The observed reduction in minimum conduction velocity suggests a mild defect in peripheral myelin in multiple sclerosis.
    • Alterations in the supernormal period further support the hypothesis of peripheral myelin involvement in MS.
    • These findings indicate that MS may impact both CNS and PNS myelin, requiring further investigation.