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Related Experiment Videos

Assessing liver function.

Samir G Sakka1

  • 1Department of Anaesthesiology and Intensive Care Medicine, Friedrich-Schiller-University of Jena, Germany. samir.sakka@med.uni-jena.de

Current Opinion in Critical Care
|March 1, 2007
PubMed
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Dynamic tests like indocyanine green plasma disappearance rate offer superior bedside assessment of liver function in critically ill patients. These methods are more sensitive than traditional markers for predicting outcomes.

Area of Science:

  • Critical care medicine
  • Hepatology
  • Diagnostic techniques

Background:

  • Assessing liver function in critically ill patients is challenging due to the lack of ideal real-time bedside techniques.
  • Traditional markers like bilirubin and serum enzymes have limitations in accuracy and sensitivity.

Purpose of the Study:

  • To review current techniques for assessing liver function in critically ill patients.
  • To evaluate the efficacy and applicability of dynamic versus static liver function tests.

Main Methods:

  • Review of existing literature on liver function assessment in critical care.
  • Comparison of dynamic tests (indocyanine green plasma disappearance rate, lidocaine metabolism) with static tests and common scoring systems.

Main Results:

Related Experiment Videos

  • Dynamic tests, particularly indocyanine green plasma disappearance rate, are superior to static tests and bilirubin for assessing liver function and predicting outcomes.
  • Indocyanine green plasma disappearance rate, measurable noninvasively at the bedside, shows high correlation with indocyanine green clearance and is more sensitive than serum enzymes.
  • Early improvement in indocyanine green plasma disappearance rate post-septic shock indicates a better prognosis.

Conclusions:

  • Dynamic tests, specifically indocyanine green plasma disappearance rate and monoethylglycinxylidide test, are recommended for liver function assessment in critically ill patients.
  • Indocyanine green plasma disappearance rate offers a noninvasive, rapid, bedside method for evaluating liver function and patient outcomes.