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Related Concept Videos

NMR Spectroscopy Of Amines01:19

NMR Spectroscopy Of Amines

In proton NMR spectroscopy, primary amines and secondary amines showcase their N–H protons as a broad signal in the chemical shift range between δ 0.5 and 5 ppm. The exact position in this range depends on several factors, including sample concentration, hydrogen bonding, and the type of solvent used. Since amine protons undergo fast proton exchange in solution, the protons are labile and therefore do not participate in any splitting with adjacent protons. Thus, the observed peak is broad and...
Indicators02:39

Indicators

Certain organic substances change color in dilute solution when the hydronium ion concentration reaches a particular value. For example, phenolphthalein is a colorless substance in any aqueous solution with a hydronium ion concentration greater than 5.0 × 10−9 M (pH < 8.3). In more basic solutions where the hydronium ion concentration is less than 5.0 × 10−9 M (pH > 8.3), it is red or pink. Substances such as phenolphthalein, which can be used to determine the pH of a solution, are called...
Physical Properties of Amines01:26

Physical Properties of Amines

Amines with low molecular weight are usually gaseous at room temperature, while those with high molecular weight are liquid or solids in nature. Usually, low molecular weight amines have a rotten fish-like smell. Diamines typically have a pungent smell. For instance, cadaverine and putrescine, depicted in Figure 1, are two molecules responsible for decaying tissue.

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Related Experiment Video

Updated: Jul 16, 2026

Qualitative Identification of Carboxylic Acids, Boronic Acids, and Amines Using Cruciform Fluorophores
09:46

Qualitative Identification of Carboxylic Acids, Boronic Acids, and Amines Using Cruciform Fluorophores

Published on: August 19, 2013

Phenanthroline-derived ratiometric chemosensor for ureas.

Yoni Engel1, Adi Dahan, Emily Rozenshine-Kemelmakher

  • 1School of Chemistry, Raymond and Beverly Sackler Faculty of Exact Sciences, Tel Aviv University, Tel Aviv 69978, Israel.

The Journal of Organic Chemistry
|March 3, 2007
PubMed
Summary

A new chemosensor (7) distinguishes between neutral ureas and their salts using optical signals. This development offers advanced analytical tools for urea and salt detection.

Related Experiment Videos

Last Updated: Jul 16, 2026

Qualitative Identification of Carboxylic Acids, Boronic Acids, and Amines Using Cruciform Fluorophores
09:46

Qualitative Identification of Carboxylic Acids, Boronic Acids, and Amines Using Cruciform Fluorophores

Published on: August 19, 2013

Area of Science:

  • Supramolecular Chemistry
  • Analytical Chemistry
  • Organic Synthesis

Background:

  • Development of selective chemosensors is crucial for detecting various chemical species.
  • Ureas and their salts are important in diverse chemical and biological applications.
  • 1,10-phenanthroline derivatives offer promising fluorophore platforms for sensing.

Purpose of the Study:

  • To synthesize and characterize novel 1,10-phenanthroline-based chemosensors.
  • To investigate the sensing capabilities of chemosensor 7 towards urea, thiourea, and related compounds.
  • To differentiate between neutral ureas and their corresponding salts using spectroscopic methods.

Main Methods:

  • Synthesis of 1,10-phenanthroline fluorophore-based chemosensor 7 and analog 9.
  • Spectroscopic analysis including 3D excitation-emission, UV-vis absorbance, and fluorescence titrations.
  • Structural elucidation via selective-NOE 1H NMR, 13C NMR, and MALDI-TOF mass spectrometry.
  • Computational analysis using DFT calculations (B3LYP 3-21g**).

Main Results:

  • Chemosensor 7 successfully distinguished between neutral ureas and uronium salts via distinct optical responses.
  • Complexation studies confirmed the interaction between chemosensor 7 and urea using NMR and mass spectrometry.
  • DFT calculations provided insights into the structural aspects of chemosensor-analyte complexes.

Conclusions:

  • Chemosensor 7 demonstrates selective recognition of urea and its salts.
  • The combination of chemosensor 7 and differential spectroscopy is a promising approach for urea analysis.
  • This work advances the development of novel analytical tools for urea and related compound detection.