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Published on: March 30, 2014

Outcomes of a multifaceted medication adherence intervention for HIV-positive patients

Kevin D Dieckhaus1, Victoria Odesina

  • 1Division of Infectious Diseases , University of Connecticut Health Center, Farmington, Connecticut 06030-3212, USA. dieckhaus@up.uchc.edu

AIDS Patient Care and Stds
|March 3, 2007
PubMed

Insights

The Connecticut HIV Medication Project (CHaMP) improved medication adherence and reduced viral load in HIV patients. This multidisciplinary program demonstrated significant positive impacts on patient outcomes for highly active antiretroviral therapy (HAART).

Area of Science:

  • Infectious Diseases
  • Public Health
  • Clinical Pharmacy

Background:

  • High adherence to highly active antiretroviral therapy (HAART) is crucial for managing HIV infection and preventing drug resistance.
  • Imperfect adherence in community settings often leads to suboptimal clinical outcomes for HIV patients.
  • The Connecticut HIV Medication Project (CHaMP) was established to address adherence challenges in HIV treatment.

Purpose of the Study:

  • To evaluate the effectiveness of the multidisciplinary CHaMP program in improving medication adherence and reducing viral load in HIV-infected patients.
  • To assess the impact of targeted interventions and follow-up on patient adherence to HAART.
  • To analyze retrospective data from patients referred to the CHaMP program for adherence support.

Main Methods:

  • Retrospective analysis of 249 HIV patients referred to CHaMP between March 2002 and January 2005.
  • Multifaceted assessment of patient adherence to antiretroviral therapy.
  • Targeted interventions and follow-up provided based on individual patient needs.
  • Analysis of self-reported adherence and plasma HIV viremia at baseline and follow-up.

Main Results:

  • Significant increase in self-reported adherence from 89.1% to 96.9% (p < 0.001) among patients with unchanged regimens.
  • Increased likelihood of reporting over 95% adherence from 36.6% to 73.1% (p < 0.001) based on 7-day recall.
  • Demonstrated improvement in plasma HIV viremia, decreasing from 3.10 +/- 1.21 log copies/mL to 2.78 +/- 0.98 log copies/mL (p < 0.01).

Conclusions:

  • The CHaMP program, a multifaceted clinical approach, significantly enhances medication adherence in HIV-infected individuals.
  • Effective adherence interventions can lead to a measurable reduction in viral burden among patients undergoing HAART.
  • Despite limitations like patient attrition, the CHaMP model shows promise for improving HIV treatment outcomes in community settings.

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