Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

And the second shall be first.

Gregory A Petsko1

  • 1Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, MA 02454-9110, USA. petsko@brandeis.edu

Genome Biology
|March 3, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The evolving landscape of protein structure and molecular recognition.

Trends in biochemical sciences·2026
Same author

RhoGEF12 regulates endosomal SORL1-retromer and its inhibition is therapeutic in human neuronal models of Alzheimer's disease.

bioRxiv : the preprint server for biology·2026
Same author

The <i>SORL1</i> p.Y1816C variant causes impaired endosomal dimerization and autosomal dominant Alzheimer's disease.

Proceedings of the National Academy of Sciences of the United States of America·2024
Same author

RIOK2 transcriptionally regulates TRiC and dyskerin complexes to prevent telomere shortening.

Nature communications·2024
Same author

Author Correction: CEACAM1 regulates TIM-3-mediated tolerance and exhaustion.

Nature·2024
Same author

On the causal role of retromer-dependent endosomal recycling in Alzheimer's disease.

Nature cell biology·2023

Structural biology's reliance on visual data can impede scientific progress. Subsequent analyses are crucial for validating initial findings and ensuring scientific accuracy.

Area of Science:

  • Structural Biology
  • Biochemistry
  • Molecular Biology

Background:

  • Protein crystal structures are vital for understanding biological mechanisms.
  • The visual nature of structural data can lead to oversimplified interpretations.
  • Initial reports may lack rigorous analysis, impacting the field.

Observation:

  • The retraction of five protein crystal structures has significantly hindered a scientific sub-field.
  • Persuasive imagery in structural biology can overshadow critical evaluation.
  • Early research publications are often superficial and error-prone.

Findings:

  • The persuasive power of 'pretty pictures' in structural biology can create scientific bottlenecks.
  • Retracted data highlights the need for critical assessment of initial structural findings.

Related Experiment Videos

  • Subsequent, more thorough analyses are essential for scientific validation.

    • Implications:

    • Over-reliance on initial structural data can delay scientific advancement.
    • Robust validation and self-correction are critical for reliable scientific progress.
    • Future research must emphasize critical evaluation of structural biology findings.