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Regulation of Food Intake01:30

Regulation of Food Intake

Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...

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Ghrelin affects gastrectomy-induced decrease in UCP1 and beta3-AR mRNA expression in mice.

Andreas Lindqvist1, Charlotta Dornonville de la Cour, Rolf Håkanson

  • 1Department of Experimental Medical Science, Lund University, Lund, Sweden. andreas.lindqvist@med.lu.se

Regulatory Peptides
|March 3, 2007
PubMed
Summary

Gastrectomy (Gx) reduces brown adipose tissue (BAT) proteins involved in thermogenesis, but ghrelin treatment can restore their expression. Stomach signals stimulate BAT UCP1, and ghrelin may control this process.

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Area of Science:

  • Endocrinology
  • Metabolism
  • Physiology

Background:

  • Brown adipose tissue (BAT) is crucial for thermogenesis, relying on beta3-adrenergic receptors (beta3-AR) and uncoupling protein 1 (UCP1).
  • Gastric function and hormones like ghrelin may influence BAT activity and energy expenditure.

Purpose of the Study:

  • To investigate the impact of gastrectomy (Gx) and ghrelin on BAT thermogenic protein expression.
  • To determine if ghrelin can counteract Gx-induced changes in UCP1 and beta3-AR mRNA levels.

Main Methods:

  • Mice underwent gastrectomy (Gx) or sham operation.
  • Animals received daily subcutaneous injections of saline or ghrelin for two or eight weeks.
  • Expression of UCP1 and beta3-AR mRNA in BAT was quantified.

Main Results:

  • Gx significantly reduced UCP1 and beta3-AR mRNA expression in BAT.
  • Eight weeks of ghrelin treatment restored UCP1 and beta3-AR mRNA levels in Gx mice to those of sham-operated controls.
  • Two weeks of ghrelin treatment decreased UCP1 and beta3-AR mRNA expression in Gx mice.
  • Ghrelin did not affect UCP1 and beta3-AR mRNA in sham-operated mice.

Conclusions:

  • Signals originating from the stomach stimulate BAT UCP1 expression and potentially thermogenesis.
  • Ghrelin plays a role in regulating UCP1 expression in brown adipose tissue, particularly after gastric surgery.