Auditory event-related potentials in Parkinson's disease: prominent correlation with attention
Hideaki Matsui1, Kazuto Nishinaka, Masaya Oda
1Department of Neurology, Sumitomo Hospital, 5-3-20 Nakanoshima, Osaka, Japan. hide0729@kuhp.kyoto-u.ac.jp
Objective:
Auditory P300 has been reported to be abnormal in demented patients with Parkinson's disease. However, it is still controversial which factors in Parkinson's disease influence P300 parameters.
Methods:
Forty patients with Parkinson's disease were included. Patients were divided into two groups: patients with dementia (PDD) and without dementia (PDND). An 'odd-ball' paradigm was used for auditory event-related potentials.
Results:
P300 latency was markedly delayed in PDD patients. Age and DRS1 (attention) were the most important factors influencing P300 latency.
Conclusions:
Although there have been reports of P300 in the past, its abnormalities reflect the deficit of attention in Parkinson's disease.
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