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Updated: Jul 16, 2026
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Proteomic Profile of EPS-Urine through FASP Digestion and Data-Independent Analysis
Published on: May 8, 2021
Advances in urinary proteome analysis and biomarker discovery
Danilo Fliser1, Jan Novak, Visith Thongboonkerd
1Mosaiques Diagnostics and Therapeutics AG, Mellendorfer Strasse 7-9, D-30625 Hannover, Germany.
Journal of the American Society of Nephrology : JASN
|March 3, 2007
Summary
Urinary proteome analysis offers new noninvasive tools for diagnosing kidney diseases and assessing prognosis. Further progress relies on data standardization and bioinformatics, not just technology.
Area of Science:
- Nephrology
- Proteomics
- Biomarker Discovery
Background:
- Noninvasive diagnosis and prognosis assessment for kidney diseases remain clinical challenges.
- Proteome analysis, particularly of urine, is advancing and may offer novel solutions.
- Urinary biomarkers hold significant potential for improving clinical nephrology.
Purpose of the Study:
- To highlight promising technological approaches for human proteome analysis.
- To discuss the applications of proteomic knowledge in clinical nephrology, focusing on the urinary proteome.
- To outline future directions and requirements for advancing proteomics in nephrology.
Main Methods:
- Review of current literature on proteomic technologies and their application to urinary analysis.
- Emphasis on technological advancements in deciphering the human proteome.
- Discussion of bioinformatics and data standardization needs.
Main Results:
- While comprehensive urinary proteome investigation is ongoing, clinical applications are already emerging.
- Current literature indicates the availability of some clinical applications from urinary proteome analysis.
- Technological advances are significant, but data standardization and bioinformatics are critical.
Conclusions:
- Proteomics is poised to play a crucial role in the future of clinical nephrology.
- Standardization of data and robust bioinformatics solutions are essential for future progress.
- Collaboration between clinicians and analytical specialists is vital for advancing urinary proteome applications.
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