Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Mitoptosis: different pathways for mitochondrial execution.

Antonella Tinari1, Tina Garofalo, Maurizio Sorice

  • 1Department of Technology and Health, Istituto Superiore di Sanita', Rome, Italy.

Autophagy
|March 3, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Supercritical CO<sub>2</sub>-Derived Tomato Extract Activates Signaling Pathways to Reduce Oxidative Stress and Inflammation in Astrocyte Cells.

Nutrients·2026
Same author

Heat-not-burn tobacco induces protein post-translational modifications and apoptosis in bronchial cells: possible role in rheumatoid arthritis.

RMD open·2026
Same author

Role of lipid rafts in the FGFR2c-mediated oncogenic signaling by involvement of TRPA1 channel in pancreatic ductal adenocarcinoma cells.

Cell death & disease·2026
Same author

Extracellular microvesicles from patients with antiphospholipid syndrome carry antigenic targets and promote endothelial cell activation <i>in vitro</i>.

Haematologica·2026
Same author

Antigenic assessment for the β2-glycoprotein I/Platelet factor 4 complex in thrombotic patients with antiphospholipid syndrome.

Frontiers in immunology·2026
Same author

Proteostasis network response to environmental chronic stress: linking survival to protein aggregation in a human neuroblastoma cellular model.

Cellular and molecular life sciences : CMLS·2025

Mitoptosis, a mitochondrial death program, may involve two distinct pathways in T cells: inner membrane mitoptosis (IMM) and outer membrane mitoptosis (OMM). Studying these could illuminate cell death and mitochondrial disease mechanisms.

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Immunology

Background:

  • Mitoptosis is a programmed cell death pathway involving mitochondria.
  • Mitochondrial dysfunction is implicated in various human diseases.
  • Existing research links mitoptosis to apoptosis, necrosis, and autophagy.

Purpose of the Study:

  • To propose two distinct pathways of mitoptosis in T cells: inner membrane mitoptosis (IMM) and outer membrane mitoptosis (OMM).
  • To explore the potential of studying these pathways for insights into cell death and mitochondrial diseases.

Main Methods:

  • Hypothesized two novel pathways based on existing literature regarding mitochondrial membrane dynamics and cell death.
  • Proposed further investigation into molecular mechanisms driving mitochondrial membrane remodeling.

Related Experiment Videos

Main Results:

  • Hypothesized IMM: loss of mitochondrial matrix and cristae with intact outer membrane.
  • Hypothesized OMM: swollen internal cristae as the sole remaining structures.
  • Identified key molecular players potentially involved in mitochondrial membrane disruption.

Conclusions:

  • Mitoptosis in T cells may proceed via distinct IMM and OMM pathways.
  • Understanding these pathways offers new avenues for research in cell death and mitochondrial pathologies.
  • Further experimental validation is required to confirm these hypothesized mechanisms.