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Updated: Jul 16, 2026
09:08
Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer
Published on: January 12, 2020
Notch, Myc and breast cancer
Argiris Efstratiadis1, Matthias Szabolcs, Apostolos Klinakis
1Department of Genetics and Development, Columbia University Medical Center, New York, New York 10032, USA. ae4@columbia.edu
Cell Cycle (Georgetown, Tex.)
|March 3, 2007
Summary
Notch signaling and Myc cooperate in oncogenesis. Notch1 directly regulates Myc, driving tumor development in breast cancer and T-cell leukemia, as shown in mouse models and human specimens.
Area of Science:
- Oncology
- Molecular Biology
- Cell Signaling
Background:
- The role of Myc in human breast cancer development is established.
- The specific role of Notch signaling in breast cancer is an emerging area of research.
- Fragmented information suggests a potential link between Notch signaling and oncogenesis.
Purpose of the Study:
- To investigate the relationship between Notch signaling and Myc in oncogenesis.
- To determine if Myc is a downstream effector of Notch1 in tumorigenesis.
- To examine the coexpression of Notch1 and Myc in human breast cancer specimens.
Main Methods:
- Utilized a mouse model where mammary tumors are induced by the intracellular domain of Notch1 (N1(IC)).
- Employed a combination of genetic and molecular analyses to study the Notch1/Myc interaction.
- Performed immunophenotyping on human breast cancer specimens to assess protein coexpression.
Main Results:
- Demonstrated that Myc is a direct transcriptional target of Notch1.
- Established Myc as an indispensable downstream effector in N1(IC)-induced tumorigenic action.
- Observed coexpression of Notch1 and Myc in a significant fraction of human breast cancer samples and in T-cell acute lymphoblastic leukemia.
Conclusions:
- Notch signaling and Myc share an oncogenic association in tumorigenesis.
- Notch1 directly regulates Myc, contributing to tumor development in breast cancer.
- The Notch1/Myc pathway is implicated in both breast cancer and T-cell acute lymphoblastic leukemia.
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