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Updated: Jul 16, 2026

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer
09:08

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer

Published on: January 12, 2020

Notch, Myc and breast cancer

Argiris Efstratiadis1, Matthias Szabolcs, Apostolos Klinakis

  • 1Department of Genetics and Development, Columbia University Medical Center, New York, New York 10032, USA. ae4@columbia.edu

Cell Cycle (Georgetown, Tex.)
|March 3, 2007
PubMed

Insights

Notch signaling and Myc cooperate in oncogenesis. Notch1 directly regulates Myc, driving tumor development in breast cancer and T-cell leukemia, as shown in mouse models and human specimens.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cell Signaling

Background:

  • The role of Myc in human breast cancer development is established.
  • The specific role of Notch signaling in breast cancer is an emerging area of research.
  • Fragmented information suggests a potential link between Notch signaling and oncogenesis.

Purpose of the Study:

  • To investigate the relationship between Notch signaling and Myc in oncogenesis.
  • To determine if Myc is a downstream effector of Notch1 in tumorigenesis.
  • To examine the coexpression of Notch1 and Myc in human breast cancer specimens.

Main Methods:

  • Utilized a mouse model where mammary tumors are induced by the intracellular domain of Notch1 (N1(IC)).
  • Employed a combination of genetic and molecular analyses to study the Notch1/Myc interaction.
  • Performed immunophenotyping on human breast cancer specimens to assess protein coexpression.

Main Results:

  • Demonstrated that Myc is a direct transcriptional target of Notch1.
  • Established Myc as an indispensable downstream effector in N1(IC)-induced tumorigenic action.
  • Observed coexpression of Notch1 and Myc in a significant fraction of human breast cancer samples and in T-cell acute lymphoblastic leukemia.

Conclusions:

  • Notch signaling and Myc share an oncogenic association in tumorigenesis.
  • Notch1 directly regulates Myc, contributing to tumor development in breast cancer.
  • The Notch1/Myc pathway is implicated in both breast cancer and T-cell acute lymphoblastic leukemia.

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