Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Integrated cell manipulation system--CMOS/microfluidic hybrid.

Hakho Lee1, Yong Liu, Donhee Ham

  • 1Department of Physics, Harvard University, Cambridge, MA 02138, USA.

Lab on a Chip
|March 3, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Recent treatment outcomes of cervical intraepithelial neoplasia in south western Uganda: a six year retrospective study.

Gynecologic oncology reports·2026
Same author

Detection of mutant cancer-derived circRNAs in extracellular vesicles by rolling circle amplification.

Molecular therapy. Nucleic acids·2026
Same author

Self-amplifying CRISPR-based one-pot ultrasensitive testing for rapid SARS-CoV-2 and its variant detection.

Biosensors & bioelectronics·2026
Same author

Smartphone-based preeclampsia diagnosis through detection of dual biomarkers - nephrin and podocalyxin.

Biosensors & bioelectronics·2026
Same author

AI in Atomic Force Microscopy: Advancing Biological Nanoscale Imaging and Autonomous Discovery.

ACS nano·2026
Same author

Engineering inertial flow patterns for signal amplification in disc-based protein assays.

Theranostics·2026

This study demonstrates a novel CMOS/microfluidic system for precise biological cell manipulation. The hybrid platform uses on-chip magnetic fields for high-speed, programmable cell control in biocompatible environments.

Area of Science:

  • Biotechnology
  • Microfluidics
  • Microelectronics

Background:

  • Cell manipulation is crucial for biological and biomedical applications.
  • Existing methods often lack precision, speed, or biocompatibility.
  • A hybrid approach integrating microelectronics and microfluidics offers potential advantages.

Purpose of the Study:

  • To demonstrate a CMOS/microfluidic hybrid system for precise biological cell manipulation.
  • To enhance the system's biocompatibility and control capabilities.
  • To present a new platform for advanced cell manipulation.

Main Methods:

  • Fabrication of a custom complementary metal-oxide semiconductor (CMOS) chip.
  • Post-fabrication of a microfluidic channel on the CMOS chip.

Related Experiment Videos

  • Utilizing an on-chip array of micro-electromagnets to generate programmable magnetic fields for cell control.
  • Redesigning the microfluidic channel and incorporating on-chip temperature sensors for enhanced biocompatibility.

    • Main Results:

    • Successful demonstration of individual biological cell manipulation using the hybrid system.
    • High-speed and programmable reconfiguration of magnetic fields achieved, enhancing manipulation capabilities.
    • Verified the advantage of the hybrid approach through cell manipulation experiments.
    • Improved biocompatibility through redesigned microfluidic channels and temperature monitoring.

    Conclusions:

    • The CMOS/microfluidic hybrid system offers a powerful new platform for cell manipulation.
    • This integrated approach enhances precision, speed, and biocompatibility in cell handling.
    • The system holds significant promise for diverse biological and biomedical applications.