Glycogen synthase kinase 3beta (GSK3beta) regulates differentiation and proliferation in neural stem cells from the
Martin H Maurer1, Jens O Brömme, Robert E Feldmann
1Department of Physiology and Pathophysiology, Division of Systems Physiology, University of Heidelberg, Im Neuenheimer Feld 326, 69120 Heidelberg, Germany. maurer@physiologie.uni-heidelberg.de
Journal of Proteome Research
|March 3, 2007
Abstract:
On the basis of its inhibition by SB216763, we identified the multifunctional enzyme Glycogen Synthase Kinase 3beta (GSK3beta) as a central regulator for differentiation and cell survival of adult neural stem cells. Detected by proteomic approaches, members of the Wnt/beta-catenin signaling pathway appear to participate in enhanced neuronal differentiation and activated transcription of beta-catenin target genes during GSK3beta inhibition, associated with decreased apoptosis.
