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Type 2 diabetes and cardiovascular disease: reducing the risk
David W Bartels1, Michael H Davidson, William C Gong
1University of Illinois at Chicago College of Pharmacy, Chicago, IL, USA. davidb@uic.edu
Journal of Managed Care Pharmacy : JMCP
|March 3, 2007
Summary
Type 2 diabetes (T2DM) significantly increases cardiovascular disease (CVD) risk. Early intervention with lifestyle changes and medications can reduce CVD complications in T2DM patients.
Area of Science:
- Cardiology
- Endocrinology
- Public Health
Background:
- Type 2 diabetes (T2DM) is a primary risk factor for cardiovascular disease (CVD).
- The increasing prevalence of T2DM contributes to CVD as a leading cause of death in the U.S.
Purpose of the Study:
- Review the pathophysiology of CVD.
- Demonstrate the links between CVD, metabolic syndrome, and T2DM.
- Discuss treatments to lower CVD risk in T2DM patients.
Main Methods:
- Literature review of T2DM and CVD pathophysiology.
- Analysis of epidemiological data on T2DM prevalence.
- Synthesis of evidence on pharmacologic and lifestyle interventions.
Main Results:
- Worldwide T2DM prevalence is higher than previously estimated.
- CVD complications represent the majority of T2DM management costs.
- Several therapeutic agents are proven to reduce CVD risk in T2DM.
Conclusions:
- Aggressive early management of T2DM and prediabetes is crucial.
- Controlling metabolic disturbances reduces CVD risk.
- Diet, exercise, and medications are key strategies for CVD risk reduction.
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